Homeobox protein Hox-B13 is a protein that in humans is encoded by the HOXB13 gene. [4][5][6] This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and …

Dec 5, 2024 · A HOXB13 mutation increases the risk for prostate cancer in males. While a HOXB13 mutation means you have a somewhat higher risk of developing cancer than the average person, it may not fully explain why your blood relatives have cancer.

The HOXB13 gene provides instructions for producing a protein that attaches (binds) to specific regions of DNA and regulates the activity of other genes. Learn about this gene and related health conditions.

Dec 25, 2024 · HOXB13 (Homeobox B13) is a Protein Coding gene. Diseases associated with HOXB13 include Prostate Cancer, Hereditary, 9 and Prostate Cancer . Among its related pathways are Chromatin Regulation / Acetylation and Regulation of Androgen receptor activity .

Nov 14, 2022 · For many years, a mutated HOXB13 gene was thought to be a risk only for men of Nordic European descent, because the G84E mutation is absent in men of African ancestry. However, in a study in Martinique, of 46 men of African descent, a new HOXB13 mutation, called X285K, was found.

Jan 12, 2012 · Probands from four families were discovered to have a rare but recurrent mutation (G84E) in HOXB13 (rs138213197), a homeobox transcription factor gene that is important in prostate development....

Mar 8, 2025 · Title: Immunoreactivity of HOXB13 in Neuroendocrine Neoplasms Is a Sensitive and Specific Marker of Rectal Well-Differentiated Neuroendocrine Tumors. Germline Variants in DNA Damage Repair Genes and HOXB13 Among …

The transcription factor HOXB13 plays crucial roles in cancer development. HOXB13 is abnormally expressed in most cancers, which makes it a valuable therapeutic target for cancer therapy. The level of HOXB13 differs significantly between healthy and cancer tissues, which indicates that the level of HOXB13 is closely related to carcinogenesis. The regulatory network …

Jul 4, 2019 · HOXB13, a homeodomain transcription factor, is linked to recurrence following radical prostatectomy. While HOXB13 regulates Androgen Receptor (AR) functions in a context dependent manner, its...

The HOXB13 protein in its normal function plays an important role in urogenital development and maintains high expression levels in the normal prostate into adulthood. Interestingly, all men with prostate cancer in the four pedigrees from the probands with …