Dec 25, 2024 · HOXA11 (Homeobox A11) is a Protein Coding gene. Diseases associated with HOXA11 include Radioulnar Synostosis With Amegakaryocytic Thrombocytopenia 1 and Radio-Ulnar Synostosis-Amegakaryocytic Thrombocytopenia Syndrome. Among its related pathways are Kidney development and Nervous system development.

Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation.

Dec 25, 2024 · HOXA11-AS (HOXA11 Antisense RNA) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with HOXA11-AS include Cervix Carcinoma and Laryngeal Squamous Cell Carcinoma.

Jun 1, 2021 · Among the four genes (Hoxa11, PR domain zinc finger protein 5, Iroquois-class homeodomain protein IRX-5 and homeobox protein PKNOX2) mapped to the GO term ‘sequence-specific DNA’, HOXA11 upregulation was associated with AML harboring MLL-t and RAS signaling mutations based on a meta-analysis using data …

该基因是 7 号染色体 A 簇的一部分，编码 DNA 结合转录因子，可调节基因表达、形态发生和分化。 该基因参与子宫发育的调节，是女性生育能力所必需的。 该基因的突变可引起伴有无巨核细胞性血小板减少症的桡尺骨骨性早闭。 [RefSeq 提供，2008 年 7 月] In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes.

HOXA11 is critical for development and maintenance of uterosacral ligaments and deficient in pelvic prolapse. HOXA gene expression is up-regulated at the ectopic implantation site in the fallopian tube and it may play a role in ectopic pregnancies.

Jul 27, 2018 · Recently, a novel identified homeobox (HOX) A11 antisense lncRNA, HOXA11-AS, 1,628 bp in length, has been excessively highlighted to be an essential initiator and facilitator in the process of malignant tumor proliferation and metastasis.

Nov 9, 2022 · We found that HOXA11-AS was significantly upregulated in glioma, and was correlated with the poor prognosis of glioma patients. Ectopic expression of HOXA11-AS promoted the proliferation,...

作为最近发现的lncrna，hoxa11反义rna（hoxa11-as）能够作为致癌或抑癌基因，在癌细胞的增殖、侵袭和迁移过程中发挥重要作用。 HOXA11-AS似乎是表观遗传修饰的主要因素，并通过多种机制对基因发挥转录、转录后、翻译和翻译后调节作用；例如，通过竞争内源 RNA ...

HOXA11 is a gene belonging to the HOX cluster that plays a role in hematologic malignancies, particularly in AML, MDS, CML, and CMML, as well as their paralogues in the B and C clusters. AI generated definition based on: Hematology (Seventh Edition), 2018