2022年2月25日 · In this minireview, we introduce the basic structure and function of HMGB1 and focus on the regulatory mechanism of HMGB1 secretion and release. Understanding these topics may help us develop...

2023年6月15日 · Fifty years since the initial discovery of HMGB1 in 1973 as a structural protein of chromatin, HMGB1 is now known to regulate diverse biological processes depending on its subcellular or...

High mobility group box 1 (HMGB1) is a nonhistone nuclear protein that has multiple functions according to its subcellular location. In the nucleus, HMGB1 is a DNA chaperone that maintains the structure and function of chromosomes. In the cytoplasm, ...

2024年12月25日 · HMGB1 (High Mobility Group Box 1) is a Protein Coding gene. Diseases associated with HMGB1 include Brachyphalangy, Polydactyly, And Tibial Aplasia/Hypoplasia and Adams-Oliver Syndrome 1. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Diseases of Immune System.

High-mobility group box 1 (HMGB1) was initially recognized as a ubiquitous nuclear protein involved in maintaining the nucleosome integrity and facilitating gene transcription. HMGB1 has since been reevaluated to be a prototypical damage-associated molecular pattern (DAMP) protein, and together with …

High mobility group box 1 (HMGB1) was first isolated and characterized in calf thymus in 1973 and is named for its electrophoretic mobility on polyacrylamide gels. HMGB1 contains two DNA-binding HMG-box domains (N-terminal A and central B) and an acidic C-terminal tail (Fig. 1A).

HMGB1 is 215 amino acids long and consists of two DNA binding boxes (A box and B box) as well as a C-terminal tail that is highly enriched in anionic residues. Reflecting this structure, HMGB1 can bind to DNA and histones, with these interactions resulting from …

In this minireview, we introduce the basic structure and function of HMGB1 and focus on the regulatory mechanism of HMGB1 secretion and release. Understanding these topics may help us develop new HMGB1-targeted drugs for various conditions, especially …

2005年4月1日 · HMGB1 is a 'leaderless' cytokine, requiring specialized means to gain access to the immunological synapse or to be secreted. By contrast, after DNA damage as a result of apoptotic cell death,...

2020年7月13日 · High mobility group box 1 (HMGB1) is a nonhistone chromatin-associated protein that has been widely reported to play a pivotal role in the pathogenesis of hematopoietic malignancies.