
High Mobility Group A1 (HMGA1): Structure, Biological Function, …
HMGA1 is a nonhistone chromatin structural protein encoded by oncogenes and located in the nucleus. It can change the structure of DNA by binding to the rills of the A+T rich region in …
HMGA1 - Wikipedia
HMGA1 preferentially binds to the minor groove of AT-rich regions in double-stranded DNA using its AT-hooks. It has little secondary structure in solution but assumes distinct conformations …
HMGA1 Gene - GeneCards | HMGA1 Protein | HMGA1 Antibody
2024年12月25日 · HMGA1 (High Mobility Group AT-Hook 1) is a Protein Coding gene. Diseases associated with HMGA1 include Type 2 Diabetes Mellitus and Lipomatosis, Familial Multiple. …
HMGA1 Modulates Gene Transcription Sustaining a Tumor …
We demonstrate that, in a triple-negative breast cancer cellular model, HMGA1 sustains the action of epigenetic modifiers and in particular it positively influences both histone H3S10 …
Scientists Identify Epigenetic Key That ‘Opens’ Door to Colon Cancer
2025年2月20日 · A gene called high mobility group A1 (HMGA1) may be the key that opens the door to the development of colon cancer, according to research led by investigators from the …
The High Mobility Group A1 (HMGA1) Transcriptome in Cancer …
HMGA1 proteins function as ancillary transcription factors that bend chromatin and recruit other transcription factors to DNA. They induce oncogenic transformation by activating or repressing …
HMGA1 orchestrates chromatin compartmentalization and
2024年8月12日 · HMGA1 is an abundant non-histone chromatin protein that has been implicated in embryonic development, cancer, and cellular senescence, but its specific role remains elusive.
Roles of HMGA proteins in cancer - Nature Reviews Cancer
HMGA1 proteins are products of the same gene, generated through alternative splicing. They are non-histone nuclear proteins known as 'architectural transcriptional factors'. HMGA gene...
HMGA - Wikipedia
HMGA is a family of high mobility group proteins characterized by an AT-hook.They code for a "small, nonhistone, chromatin-associated protein that has no intrinsic transcriptional activity …
HMGA1 acts as an epigenetic gatekeeper of ASCL2 and Wnt
2025年2月3日 · Here, we uncover a previously unknown epigenetic program whereby HMGA1 amplifies Wnt signaling during colon tumorigenesis driven by inflammatory microbiota and/or …