HMGA1 is a nonhistone chromatin structural protein encoded by oncogenes and located in the nucleus. It can change the structure of DNA by binding to the rills of the A+T rich region in …

HMGA1 preferentially binds to the minor groove of AT-rich regions in double-stranded DNA using its AT-hooks. It has little secondary structure in solution but assumes distinct conformations …

2024年12月25日 · HMGA1 (High Mobility Group AT-Hook 1) is a Protein Coding gene. Diseases associated with HMGA1 include Type 2 Diabetes Mellitus and Lipomatosis, Familial Multiple. …

We demonstrate that, in a triple-negative breast cancer cellular model, HMGA1 sustains the action of epigenetic modifiers and in particular it positively influences both histone H3S10 …

2025年2月20日 · A gene called high mobility group A1 (HMGA1) may be the key that opens the door to the development of colon cancer, according to research led by investigators from the …

HMGA1 proteins function as ancillary transcription factors that bend chromatin and recruit other transcription factors to DNA. They induce oncogenic transformation by activating or repressing …

2024年8月12日 · HMGA1 is an abundant non-histone chromatin protein that has been implicated in embryonic development, cancer, and cellular senescence, but its specific role remains elusive.

HMGA1 proteins are products of the same gene, generated through alternative splicing. They are non-histone nuclear proteins known as 'architectural transcriptional factors'. HMGA gene...

HMGA is a family of high mobility group proteins characterized by an AT-hook.They code for a "small, nonhistone, chromatin-associated protein that has no intrinsic transcriptional activity …

2025年2月3日 · Here, we uncover a previously unknown epigenetic program whereby HMGA1 amplifies Wnt signaling during colon tumorigenesis driven by inflammatory microbiota and/or …