HLA-G histocompatibility antigen, class I, G, also known as human leukocyte antigen G (HLA-G), is a protein that in humans is encoded by the HLA-G gene. [5] HLA-G belongs to the HLA nonclassical class I heavy chain paralogues. Classical HLA I proteins are found on all nucleated cells and express peptides in their peptide binding groove.

人类白细胞抗原 -G (human leukocyte antigen-G，HLA-G)是位于人第6号染色体短臂上的一群紧密连锁基因群，属于人类一种非经典的主要组织相容性复合体 (major histocompatibility complex，MHC)的I类分子，选择性高表达于侵入子宫蜕膜的绒毛外滋养细胞。 妊娠被认为是成功的同种异体移植，很多妊娠相关疾病与滋养细胞异常增殖、浸润、胎盘形成不良有关。 HLA-G在母胎界面的表达对母胎免疫耐受和维持正常妊娠有重要作用，但HLA-G的具体生物学作用，尤其 …

Human leukocyte antigen G (HLA-G) mediates maternal-fetal immune tolerance. It is also considered an immune checkpoint in cancer since it may mediate immune evasion and thus promote tumor growth. HLA-G is, therefore, a potential target for ...

2024年12月25日 · HLA-G (Major Histocompatibility Complex, Class I, G) is a Protein Coding gene. Diseases associated with HLA-G include Asthma and Severe Pre-Eclampsia. Among its related pathways are SARS-CoV-2 Infection and Infectious disease. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity …

HLA-G is a non-classical HLA class I molecule with immunomodulatory properties. It was initially described at the maternal-fetal interface, and it was later found that this molecule was constitutively expressed on certain immuneprivileged tissues, such as cornea, endothelial and erythroid precursors, and thymus.

hla-g表达是肿瘤细胞逃逸免疫监视的手段之一，许多研究都关注hla-g表达与肿瘤患者生存率之间的关系。 mHLA-G可以通过“Trogocytosis”的机制实现肿瘤对NK细胞的抑制功能，而sHLA-G则可以通过诱导T细胞分化CD4+CD25+FoxP3+Treg细胞而实现肿瘤细胞逃避免疫监视。

In this review, the major features of the HLA-G gene relevant for the knowledge of HLA-G structure, function, disease association and evolution will be addressed.

2021年11月29日 · We characterized the HLA-G genetic variability in 4640 individuals from 88 different population samples across the globe by using a state-of-the-art method to characterize polymorphisms and...

HLA-G immune modulatory genes and molecules are presently being studied by a widespread number of research groups. In the present study, we do not aim to be exhaustive since the number of manuscripts published every year is overwhelming. Instead, our aim is pointing out facts about HLA-G function, p …

hla-g 属于 hla i 类重链旁系同源物。这种 i 类分子是由重链和轻链 (β2 微球蛋白) 组成的异二聚体。重链锚定在膜中。 hla-g 在胎儿来源的胎盘细胞上表达。重链约为 45 kda，其基因包含 8 个外显子。