Allopurinol Hypersensitivity Assay HLA-B*58:01 Genotyping - AAFP
2019年11月1日 · The allopurinol hypersensitivity assay, or HLA-B*58:01 test, is a blood test to detect the presence of a human leukocyte antigen B (HLA-B) genetic variant that increases the risk of...
HLA-B*58:01 Typing | Test Detail | Quest Diagnostics
HLA-B*58:01 Typing - HLA B*58:01 has been associated with severe cutaneous adverse reactions (SCAR) in response to the drug Allopurinol.
HL58R - Overview: HLA-B*5801 Genotype, Allopurinol …
Identifying individuals with an increased risk of severe cutaneous adverse reactions to allopurinol based on the presence of the human leukocyte antigen HLA-B*58:01 allele. Qualitative Allele-Specific Real-Time Polymerase Chain Reaction (PCR)
Allopurinol Therapy and HLA-B*58:01 Genotype
2013年3月26日 · We conditionally recommend testing HLA–B*58:01 before starting allopurinol for individuals of Southeast-Asian descent (for example, Han-Chinese, Korean, Thai) and African-American individuals, who have a higher prevalence of HLA–B*5801.
HLA-B58 - Wikipedia
HLA-B58 (B58) is an HLA - B serotype. B58 is a split antigen from the B17 broad antigen, the sister serotype B57. [1] . The serotype identifies the more common HLA-B*58 gene products. [2] ( For terminology help see: HLA-serotype tutorial) B*5801 is associated with allopurinol induced inflammatory necrotic skin disease.
HLA-B*58:01 Genotyping, Allopurinol Hypersensitivity
HLA-B*58:01 genotyping can be used to identify patients who are at increased risk for developing severe cutaneous adverse reactions (SCAR) after treatment with allopurinol, based on the presence of the HLA-B*58:01 allele.
HLA-B*5801 Screening Before Allopurinol Administration to …
A recent systematic review and meta-analysis found that HLA-B*5801 screening for detecting allopurinol-associated SJS or TEN is effective and may help reduce the risk of allopurinol-associated SJS or TEN. 15 Specifically, this review found allopurinol associated with TEN and SJS related to Korean, Thai, Sardinian Italian, Han Chinese, Japanese ...
HLA-B*5801 allele as a genetic marker for severe cutaneous ... - PubMed
2005年3月15日 · HLA alleles A*3303, Cw*0302, and DRB1*0301 were in linkage disequilibrium and formed an extended haplotype with HLA-B*5801. Our results indicated that allopurinol-SCAR is strongly associated with a genetic predisposition in Han Chinese.
Diagnostic utility of HLA-B*5801 screening in severe ... - PubMed
Screening of HLA-B*5801 may help patients to prevent the occurrence of allopurinol-induced TEN/SJS, especially in populations with a higher (≥ 5%) risk allele frequency. Keywords: HLA-B*5801; allopurinol; gout; hypersensitivity; meta-analysis; screening.
Validation of a Rapid, Robust, Inexpensive Screening Method for ...
Therefore, we developed a rapid, robust, inexpensive screening method using SYBR® Green real time PCR to detect the HLA-B * 58:01 allele. A total of 119 samples were tested.