Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重 …

Jan 27, 2011 · We hypothesize that HFE modulates erythropoiesis by affecting dietary iron absorption and erythroid iron intake. To investigate this, we used Hfe -KO mice in conditions of …

Our data provide evidence that both wt- and Hfe-KO-derived chondrocytes, when exposed to 50 μM iron, develop characteristics of an OA-related phenotype, such as an increased expression …

Results: Hfe-KO mice showed a systemic iron overload and an increased iron accumulation in the knee synovial membrane following surgery. The histological OA score was significantly higher …

In summary, we have developed a new tool for gene therapy that increases expression of Hamp in the liver, partially reversing the hemochromatosis phenotype. Finally, studies are in progress …

Our data provide evidence that both wt- and Hfe -KO-derived chondrocytes, when exposed to 50 μM iron, develop characteristics of an OA-related phenotype, such as an increased expression …

携带突变Hfe基因的鼠与Cre敲除品系杂交后，后代保留了新霉素抗性基因座，但缺失了编码α-2、α-3和跨膜区的3-5个外显子。RT-PCR结果显示异常的转录本，它将2号外显子与6号外显子连接 …

江苏集萃药康生物科技股份有限公司成立于2017年，是一家专业从事实验动物小鼠模型的研发、生产、销售及相关技术服务的高新技术企业。

Feb 14, 2018 · We found increased neuronal cell death, vascular alterations and loss of retinal barrier integrity in diabetic HFE KO mice compared to diabetic wildtype mice. Diabetic HFE KO …

We hypothesize that HFE modulates erythropoiesis by affecting dietary iron absorption and erythroid iron intake. To investigate this, we used Hfe -KO mice in conditions of altered dietary …