
HERC2 Gene - GeneCards | HERC2 Protein | HERC2 Antibody
2024年12月25日 · HERC2 (HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 2) is a Protein Coding gene. Diseases associated with HERC2 include Intellectual Developmental …
HERC2 - an overview | ScienceDirect Topics
HERC2 belongs to the HERC gene family, localized on chromosome 15q13.1, and encodes a large protein consisting of 4834 amino acids. You might find these chapters and articles …
Functional and pathological relevance of HERC family proteins: a …
In humans, the HERC family comprises six members that can be divided into two groups based on their molecular mass and domain structure. Whereas large HERCs (HERC1 and HERC2) …
Novel loss-of-function mutation in HERC2 is associated with …
The HERC2 gene encodes a 527 kDa E3 ubiquitin protein ligase that has key roles in cell cycle regulation, spindle formation during mitosis, mitochondrial functions and DNA damage …
HERC2 promotes inflammation-driven cancer stemness and …
2023年2月1日 · HERC2 enhanced the stemness and PD-L1-mediated immune evasion of HCC cells, which is associated with the activation of signal transducer and activator of transcription …
HERC2 is an E3 ligase that targets BRCA1 for degradation
2010年8月1日 · Here, we show that HERC2, a protein recently implicated in DNA damage repair, targets BARD1-uncoupled BRCA1 for degradation. HERC2 shuttles between the nucleus and …
HERC2 coordinates ubiquitin-dependent assembly of DNA …
2009年12月20日 · Here, we identify HERC2 as a factor that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. In response to ionising radiation (IR), …
HERC Ubiquitin Ligases in Cancer - PMC
HERC1 and HERC2 are the largest HECT ligases, having molecular weights exceeding 500 kDa, and constitute the large HERC protein subfamily [3]. By contrast, HERC3 to HERC6 have …
Human Gene HERC2 (ENST00000261609.13) from GENCODE V47
2024年8月16日 · There are several single nucleotide polymorphisms within the OCA2 gene and within the HERC2 gene that have a statistical association with human eye color. SIMILARITY: …
HERC2 HECT and RLD domain containing E3 ubiquitin protein …
2024年1月7日 · HERC2 promotes inflammation-driven cancer stemness and immune evasion in hepatocellular carcinoma by activating STAT3 pathway. Liu Y, Xu Q, Deng F, Zheng Z, Luo J, …
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