
HDAC9 Gene - GeneCards | HDAC9 Protein | HDAC9 Antibody
2024年12月25日 · HDAC9 (Histone Deacetylase 9) is a Protein Coding gene. Diseases associated with HDAC9 include Auriculocondylar Syndrome 4 and Primary Cutaneous T-Cell Non-Hodgkin Lymphoma. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Gene expression (Transcription).
HDAC9 | Circulation Research - AHA/ASA Journals
2020年8月27日 · HDAC9 (histone deacetylase 9) actions in atherosclerosis. HDAC9 risk alleles can increase HDAC9 expression. HDAC9 interacts with IKKs (inhibitory kappa B kinases), leading to their deacetylation and activation.
Histone Deacetylase 9: Its Role in the Pathogenesis of Diabetes …
As a member of the class IIa histone deacetylases (HDACs), HDAC9 catalyzes the deacetylation of histones and transcription factors, commonly leading to the suppression of gene transcription. The activity of HDAC9 is regulated transcriptionally and post-translationally.
Histone deacetylase (HDAC) 9: versatile biological functions …
This review summarizes the most recent discoveries regarding HDAC9 as a crucial regulator of specific physiological systems and, more importantly, highlights the diverse spectrum of HDAC9-mediated posttranslational modifications and their contributions to cancer pathogenesis.
HDAC9-mediated epithelial cell cycle arrest in G2/M ... - Nature
2023年5月25日 · Here, the authors show that HDAC9 is upregulated in the fibrotic kidney and promotes epithelial cell cycle arrest in G2/M by regulating STAT1.
Identification of HDAC9 as a viable therapeutic target for the ...
2019年8月26日 · Our findings suggest that the development of HDAC9-selective HDACis is a potential approach to improve the efficacy of chemotherapy and reduce systemic toxicity.
9734 - Gene ResultHDAC9 histone deacetylase 9 [ (human)]
CircHDAC9 regulates myocardial ischemia-reperfusion injury via miR-671-5p/SOX4 signaling axis. Identification of HDAC9 and ARRDC4 as potential biomarkers and targets for treatment of type 2 diabetes.
HDAC9: An inflammatory link in atherosclerosis - PMC - PubMed …
HDAC9 deletion or pharmacological inhibition by TMP195 inhibits such inflammatory phenotypes and ameliorates atherosclerosis and enhances plaque stability in mice. Certain HDAC inhibitors are already in clinical use for certain cancers 11. They have also been tested in experimental models of CVD with varied outcomes.
The CREscendoing promise of HDAC targeting to limit …
4 天之前 · HDAC9, encoding the signal-responsive histone deacetylase 9 (HDAC9), is a major risk locus for myocardial infarction, stroke, and other vascular disorders.In mouse models of atherosclerosis, HDAC9 has a proatherogenic role via the binding and deacetylation of IκB kinase (IKK). 4, 5 The lead variant of HDAC9, rs2107595, mediates allele-specific transcriptional …
A cis-regulatory element controls expression of histone …
2025年1月28日 · Common genetic variants in a cis-regulatory element at HDAC9, which regulates expression of the histone deacetylase HDAC9, are a major risk factor for cardiovascular disease.
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