2024年12月25日 · HDAC9 (Histone Deacetylase 9) is a Protein Coding gene. Diseases associated with HDAC9 include Auriculocondylar Syndrome 4 and Primary Cutaneous T-Cell Non-Hodgkin Lymphoma. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Gene expression (Transcription).

2020年8月27日 · HDAC9 (histone deacetylase 9) actions in atherosclerosis. HDAC9 risk alleles can increase HDAC9 expression. HDAC9 interacts with IKKs (inhibitory kappa B kinases), leading to their deacetylation and activation.

As a member of the class IIa histone deacetylases (HDACs), HDAC9 catalyzes the deacetylation of histones and transcription factors, commonly leading to the suppression of gene transcription. The activity of HDAC9 is regulated transcriptionally and post-translationally.

This review summarizes the most recent discoveries regarding HDAC9 as a crucial regulator of specific physiological systems and, more importantly, highlights the diverse spectrum of HDAC9-mediated posttranslational modifications and their contributions to cancer pathogenesis.

2023年5月25日 · Here, the authors show that HDAC9 is upregulated in the fibrotic kidney and promotes epithelial cell cycle arrest in G2/M by regulating STAT1.

2019年8月26日 · Our findings suggest that the development of HDAC9-selective HDACis is a potential approach to improve the efficacy of chemotherapy and reduce systemic toxicity.

CircHDAC9 regulates myocardial ischemia-reperfusion injury via miR-671-5p/SOX4 signaling axis. Identification of HDAC9 and ARRDC4 as potential biomarkers and targets for treatment of type 2 diabetes.

HDAC9 deletion or pharmacological inhibition by TMP195 inhibits such inflammatory phenotypes and ameliorates atherosclerosis and enhances plaque stability in mice. Certain HDAC inhibitors are already in clinical use for certain cancers 11. They have also been tested in experimental models of CVD with varied outcomes.

4 天之前 · HDAC9, encoding the signal-responsive histone deacetylase 9 (HDAC9), is a major risk locus for myocardial infarction, stroke, and other vascular disorders.In mouse models of atherosclerosis, HDAC9 has a proatherogenic role via the binding and deacetylation of IκB kinase (IKK). 4, 5 The lead variant of HDAC9, rs2107595, mediates allele-specific transcriptional …

2025年1月28日 · Common genetic variants in a cis-regulatory element at HDAC9, which regulates expression of the histone deacetylase HDAC9, are a major risk factor for cardiovascular disease.