Histone deacetylase 7 is an enzyme that in humans is encoded by the HDAC7 gene. [5][6][7] Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA.

2024年12月25日 · HDAC7 (Histone Deacetylase 7) is a Protein Coding gene. Diseases associated with HDAC7 include Hematologic Cancer and Epilepsy. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST …

2024年2月27日 · HDAC7 facilitates β-catenin redistribution to the nucleus by deacetylating β-catenin and inhibiting its phosphorylation, which results in that the nuclear accumulation of β-catenin binds to TCF/LEF to activate related gene expression.

HDAC7 promotes the growth of human and mouse AEL cells both in vitro and in vivo through its non- enzymatic functions. Our study provides experimental evidence that TP53 deficiency and ERG ...

2022年3月11日 · HDAC7 overexpression remarkably enhanced cell migration verified by scratch wound assay and transwell assay (Fig. 2a and b) and suggested that HDAC7 overexpression promoted the epithelial–mesenchymal transition (EMT) of the cells.

2010年12月1日 · In this study, we performed RNA interference targeting HDAC7 in human tumor cell lines and demonstrated that HDAC7 silencing was effective in inhibiting cancer cell proliferation via arresting cell cycle progression and reactivating cellular senescence in a c-Myc-dependent manner.

HDAC7 is involved in regulation of myocyte migration and differentiation. Known interaction partners of class IIa HDAC7 are myocyte enhancer factors - MEF2A, -2C, and -2D, 14-3-3 proteins, SMRT and N-CoR co-repressors, HDAC3, ETA (endothelin receptor).

2020年5月4日 · We found that SIK1 phosphorylated and stabilized histone deacetylase 7 (HDAC7) protein during cardiac stress, an event that is required for pathologic cardiomyocyte remodeling.

We found that HDAC1 and HDAC3 inhibition or knockdown results in HDAC7 downregulation, which is associated with a decrease in histone 3 lysine 27 acetylation (H3K27ac) at transcription start...

2011年4月15日 · We report that HDAC7 is exported from the cell nucleus during positive selection in mouse thymocytes and that it regulates genes mediating the coupling between TCR engagement and downstream events that determine cell survival.