Nov 20, 2024 · Here we identify that human histone deacetylase 6 (HDAC6) serves as a valine sensor by directly binding valine through a primate-specific SE14 repeat domain. The nucleus and cytoplasm...

We propose that an alteration of HDAC6 early during the disease causes both memory dysfunction and precipitates, since HDAC6 has functional domains for both processes. Epigenetics and histone modifications are crucial events in diseases of cognition, neurodegeneration, and development.

Dec 25, 2024 · HDAC6 (Histone Deacetylase 6) is a Protein Coding gene. Diseases associated with HDAC6 include Chondrodysplasia With Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, And Microphthalmia and Bone Disease. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Selective autophagy.

Histone deacetylase (HDAC) inhibitors have been demonstrated to be beneficial in animal models of neurodegenerative diseases. Such results were mainly associated with the epigenetic modulation caused by HDACs, especially those from class I, via chromatin deacetylation.

Jul 25, 2016 · Histone deacetylase 6 (HDAC6) is a critical target for drug design because of its role in oncogenic transformation and cancer metastasis, and is unique among all histone deacetylases in that...

Dec 23, 2020 · Here, we review recent findings and novel conclusions on the role of HDAC6 in neurodegeneration. Selective studies with pan-HDACi are also included. We propose that an early alteration of HDAC6 undermines synaptic transmission, while altering transport and aggregation, eventually leading to neurodegeneration.

Histone deacetylases 6 (HDAC6) has emerged as a promising target for the treatment of various human diseases including cancer, neurodegenerative disease and immunology due to its unique structure, substrate and biological functions.

Apr 15, 2020 · Histone deacetylase 6 (HDAC6) plays a central role in various processes that are key for neuronal survival. In this review, we summarize the current evidence related to disease pathways in the axonal form of Charcot-Marie-Tooth disease (CMT) and highlight the role of HDAC6 in these pathways.

Histone deacetylase 6 (HDAC6) belongs to a class of epigenetic targets that have been found to be a key protein in the association between tumors and cardiovascular disease. Recent studies have focused on the crucial role of HDAC6 in regulating ...

Feb 9, 2025 · HDAC6: A unique HDAC family member as a cancer target. HDAC6 Inhibition Alleviates Ischemia- and Cisplatin-Induced Acute Kidney Injury by Promoting Autophagy. The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6.