
Human HDAC6 senses valine abundancy to regulate DNA damage
2024年11月20日 · Here we identify that human histone deacetylase 6 (HDAC6) serves as a valine sensor by directly binding valine through a primate-specific SE14 repeat domain. The nucleus and cytoplasm...
HDAC6 in Diseases of Cognition and of Neurons - PMC - PubMed …
We propose that an alteration of HDAC6 early during the disease causes both memory dysfunction and precipitates, since HDAC6 has functional domains for both processes. Epigenetics and histone modifications are crucial events in diseases of cognition, neurodegeneration, and development.
HDAC6 as a target for neurodegenerative diseases: what makes it ...
Histone deacetylase (HDAC) inhibitors have been demonstrated to be beneficial in animal models of neurodegenerative diseases. Such results were mainly associated with the epigenetic modulation caused by HDACs, especially those from class I, via chromatin deacetylation.
HDAC6 Gene - GeneCards | HDAC6 Protein | HDAC6 Antibody
2024年12月25日 · HDAC6 (Histone Deacetylase 6) is a Protein Coding gene. Diseases associated with HDAC6 include Chondrodysplasia With Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, And Microphthalmia and Bone Disease. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Selective autophagy.
HDAC6 in Diseases of Cognition and of Neurons - PubMed
2020年12月23日 · Here, we review recent findings and novel conclusions on the role of HDAC6 in neurodegeneration. Selective studies with pan-HDACi are also included. We propose that an early alteration of HDAC6 undermines synaptic transmission, while altering transport and aggregation, eventually leading to neurodegeneration.
Histone deacetylase 6 structure and molecular basis of catalysis …
2016年7月25日 · Histone deacetylase 6 (HDAC6) is a critical target for drug design because of its role in oncogenic transformation and cancer metastasis, and is unique among all histone deacetylases in that...
HDAC6: A unique HDAC family member as a cancer target
2022年8月29日 · HDAC6 is a regulator of multiple vital cellular processes and pathways, which are essential not only for physiological homeostasis, but also account for the various stages of multistep tumor formation including initiation, promotion, progression and …
10013 - Gene ResultHDAC6 histone deacetylase 6 [ (human)]
2025年2月9日 · HDAC6: A unique HDAC family member as a cancer target. HDAC6 Inhibition Alleviates Ischemia- and Cisplatin-Induced Acute Kidney Injury by Promoting Autophagy. The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6.
Structure, Functions and Selective Inhibitors of HDAC6
Histone deacetylases 6 (HDAC6) has emerged as a promising target for the treatment of various human diseases including cancer, neurodegenerative disease and immunology due to its unique structure, substrate and biological functions.
Histone deacetylase 6 in health and disease - PubMed
In this review, we discuss structural features of this histone deacetylase, regulation of its expression and activity, biological functions, implication in human disease initiation and progression. Finally will describe novel and selective HDAC6 inhibitors.
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