Dec 25, 2024 · HDAC4 (Histone Deacetylase 4) is a Protein Coding gene. Diseases associated with HDAC4 include Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies and Chromosome 2Q37 Deletion Syndrome. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Gene expression (Transcription).

Among class II HDACs, HDAC4 is implicated in controlling gene expression important for diverse cellular functions. Basic and clinical experimental evidence have well established that HDAC4 performs a wide variety of functions.

HDACs are divided into three distinct classes: I, II, and III, on the basis of size and sequence homology, as well as formation of distinct complexes. Among class II HDACs, HDAC4 is implicated in controlling gene expression important for diverse cellular functions.

The HDAC4 gene provides instructions for making an enzyme called histone deacetylase 4. This enzyme is part of a group of related enzymes, called histone deacetylases, that modify proteins called histones.

The main achievement of HDACs on histones is to repress transcription and promote the formation of more compact chromatin. There are 18 different HDACs encoded in the human genome. Here we will discuss HDAC4, a member of the class IIa family, and its possible contribution to cancer development.

Histone deacetylase 4 (HDAC4), a class IIa HDAC, has gained attention as a potential therapeutic target in treating inflammatory and metabolic processes based on its essential role in various biological pathways by deacetylating non-histone proteins, including transcription factors.

HDAC4 is a target gene of miR-140 and is involved in miR-140-mediated suppression of osteosarcoma cells. HDAC4 increases endogenous SIRT1 expression by enhancing its sumoylation modification levels; downregulated in sustained virologic responders compared to the spontaneous clearers of Hepatitis C

Nov 9, 2012 · We found that HDAC4, a histone deacetylase that shuttles between the nucleus and cytoplasm, controls a transcriptional program essential for synaptic plasticity and memory. The nuclear import of HDAC4 and its association with …

Oct 15, 2019 · HDAC4, a class IIa histone deacetylase, is upregulated in skeletal muscle in response to denervation-induced atrophy. When HDAC4 is deleted postnatally, mice are partially protected from denervation. Despite the name “histone” deacetylase, HDAC4 demonstrably deacetylates cytosolic and non-histone nuclear proteins.

HDAC4 is a class II HDAC, and mutations in this gene causes defects in learning and memory and long-term synaptic potentiation in mice [185,186]. Mouse HDAC4 associates with neuronal chromatin to repress synaptic genes in the absence of NMDA signaling [185]. NMDA signaling is thought to be activated during learning, causing shuttling of HDAC4 ...