组蛋白去乙酰化酶11 (histone deacetylases 11, HDAC11) 是IV 类HDAC 的唯一成员，能够催化组蛋白和非 组蛋白赖氨酸残基去乙酰化并具有去脂酰化活性。 HDAC11 与免疫细胞的成熟、分化和功能密切相关，多

Dec 25, 2024 · HDAC11 (Histone Deacetylase 11) is a Protein Coding gene. Diseases associated with HDAC11 include Mature T-Cell And Nk-Cell Lymphoma and Peripheral T-Cell Lymphoma. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Gene expression (Transcription).

Histone deacetylase 11 is a 39kDa histone deacetylase enzyme that in humans is encoded by the HDAC11 gene on chromosome 3 in humans and chromosome 6 in mice. [5] [6] It is the only Class IV HDAC since it is not highly homologous with either Rpd3 or hda1 yeast enzymes and so does not fit into either Class I or Class II. [7]

The histone deacetylases (HDACs) family of enzymes possess deacylase activity for histone and nonhistone proteins; HDAC11 is the latest discovered HDAC and the only member of class IV. Besides its shared HDAC family catalytical activity, recent studies underline HDAC11 as a multifaceted enzyme with …

hdac8和hdac11则优先水解非乙酰酰基赖氨酸底物，hdac10则是一种多胺去乙酰化酶。 HDAC催化机制 乙酰赖氨酸底物位于一个由疏水残基围绕的狭窄通道中，其中酪氨酸残基通过构象翻转与羰基氧形成氢键（图A）。

Sep 6, 2021 · 唯一的Ⅳ类hdac是hdac11，其与Ⅰ类和Ⅱ类酶的催化核心区域具有序列同源性，但是不具有足够的相似性。 图片来源：ResearchGate HDAC抑制剂是潜在的抑制增殖的化合物，它可以诱导细胞凋亡。

Mar 12, 2022 · This study provided evidence that HDAC11 is highly expressed in the aortic intima of HFD-fed ApoE −/− mice and HDAC11 knockdown significantly suppressed pyroptosis via inhibiting NLRP3/caspase...

Nov 16, 2008 · Here we show that HDAC11, a member of the HDAC histone deacetylase family with no prior defined physiological function, negatively regulated expression of the gene encoding interleukin 10 (IL-10...

Sep 3, 2023 · Histone deacetylase 11 (HDAC11) is a unique member of the histone deacetylase family that plays an important role in the regulation of gene expression and protein function. In recent years, research on the role of HDAC11 in tumors has attracted increasing attention. This review summarizes the curren …

组蛋白去乙酰化酶(histone deacetylase,HDAC)是一类蛋白酶,对染色体的结构修饰和基因表达调控发挥着重要的作用。一般情况下,组蛋白的乙酰化有利于DNA与组蛋白八聚体的解离，核小体结构松弛，从而使各种转录因子和协同转录因子能与DNA结合位点特异性结合，激活基因的转录。