The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels play a crucial role in regulating neuronal excitability. Despite growing evidence supporting the therapeutic potential of HCN1 inhibition in treating neurological disorders, the ...

2024年12月25日 · Complete information for HCN1 gene (Protein Coding), Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 1, including: function, proteins, disorders, pathways, orthologs, and expression.

We determined structures of the human HCN1 channel expressed without its C-terminus to improve its stability in detergent . The truncated channel, HCN1 EM, is activated by membrane hyperpolarization, is cation permeable like the full-length channel, and is sensitive to cAMP (Figure S2A–D).

HCN1 is part one of four paralogous genes that encode the hyperpolarization- activated cyclic nucleotide-gated channels. HCN1 conducts a hyperpolarization- activated current in the brain. The depolarization promotes neuronal firing and, when excessive, neuronal hyperexcitability.

2025年2月8日 · HCN1 channels: A versatile tool for signal processing by primary sensory neurons. Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice. Downregulation of hyperpolarization-activated cyclic nucleotide-gated channels (HCN) in the hippocampus of patients with medial temporal lobe epilepsy ...

Pathogenic variation in HCN1 is now an established cause of epilepsy and intellectual disability. Variation in HCN1 causes a spectrum of disease with a genotype–phenotype relationship emerging.

2025年2月8日 · HCN1 contributes substantially to hyperpolarization-activated current properties in individual cortical plate neurons; HCN1 stabilizes the leading pacemaker region within the sinoatrial node and hence is crucial for stable heart rate and regular beat-to-beat variation.

2025年2月8日 · Hcn1 is a tremorgenic genetic component in a rat model of essential tremor. High HCN1 expression induced by status epilepticus is responsible for epileptogenesis. Data indicate that HCN1 and HCN2 form alternate ternary protein complexes with hair-cell stereociliary proteins.

2017年1月12日 · Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels underlie the control of rhythmic activity in cardiac and neuronal pacemaker cells. In HCN, the polarity of voltage dependence is uniquely reversed.

2024年10月8日 · Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels generate the cationic I h current in neurons and regulate the excitability of neuronal networks. The function of HCN channels depends, in part, on their subcellular localization. Of the four HCN isoforms (HCN1-4), HCN1 is …