H3S10P is an epigenetic modification to the DNA packaging protein histone H3. It is a mark that indicates the phosphorylation the 10th serine residue of the histone H3 protein. Depending on the environment in which it happens, the same phosphorylated residue might have drastically different consequences on chromatin structure.

2020年10月14日 · Phosphorylation of serine 10 on histone H3 (H3S10ph) is an unique histone modification as it is involved in two structurally opposed processes: transcriptional activation and chromatin relaxation, or chromosome compaction during cell division [7, 8, 9, 10, 11, 12, 13, 14].

2005年10月12日 · Here we show that antibodies against mitotic chromosomal antigens that are associated with human autoimmune diseases 9 specifically recognize H3 molecules that are modified by both...

2020年10月14日 · One of them is the phosphorylation of serine 10 on histone H3 (H3S10ph). Main body: H3S10ph is emerging as an important player in the initiation and propagation of cancer, as it facilitates cellular malignant transformation and …

Our results indicate that H3S10P presents a remarkable distribution pattern in preimplantation mouse embryos until the 4-cell stage and is a better marker of pericentromeric heterochromatin than HP1β. After the 8-cell stage, H3S10P kinetic is more similar to the somatic one, initiating during G2 in chromocenters and disappearing upon telophase.

2019年11月25日 · The chromosomal kinase JIL-1 is responsible for interphase histone H3S10 phosphorylation and has been proposed to protect active chromatin from heterochromatinisation.

Phosphorylation of histone H3 serine 10 (p-H3S10) is tightly associated with cell cycle progression; it also occurs when cells are exposed to certain environmental stresses or growth stimuli . Although p-H3S10 is minimal in interphase, it …

2013年11月21日 · Histone H3S10 plays a key role in maintaining genome stability, as scored by ectopic recombination and plasmid loss, Rad52 foci, and Rad53 checkpoint activation. H3S10P coincides with the presence of DNA-RNA hybrids, is suppressed by ribonuclease H overexpression, and causes reduced accessibility of restriction endonucleases, implying a tight ...

H3S10ph broadly demarcates gene-rich regions in G1 and is positively correlated with domains of early DNA replication timing (RT) but negatively correlated with H3K9me2 and lamin-associated domains (LADs).

2003年9月15日 · Phosphorylation of Ser10 in the tails of histone H3 has been extensively studied in many organisms. Interestingly, this modification is involved in both transcription and cell division, two events requiring opposite alterations in the degree of chromatin compaction. How does one and the same modification of histone H3 fulfil such roles?