Cell丨许瑞明/张志国合作组解析催化H3K56乙酰化的分子机制—— …
H3K56Ac有别于其他位点的乙酰化修饰，这是一个位于核小体内部的球形区修饰，它的发现是表观遗传领域的一个小高潮。 围绕H3K56Ac修饰，众多科学家致力于揭示该修饰的功能，寻找该 …
H3K56 acetylation regulates chromatin maturation following DNA ...
Jan 2, 2025 · Here, we show that histone H3K56 acetylation (H3K56ac), a mark on newly-synthesized H3, facilitates the remodeling of disorganized nucleosomes in nascent chromatin, …
分子动力学模拟揭示 H3K56 乙酰化如何影响核小体结构以促进 …
大量研究表明，H3 组蛋白 (H3K56ac) 56 位赖氨酸乙酰化在各种 DNA 事务中发挥着重要作用，包括对 DNA 损伤的反应及其与人类癌症的关联。 生物物理学研究表明，H3K56ac 通过促进 …
Distinct transcriptional roles for Histone H3-K56 acetylation …
Sep 26, 2019 · Histone H3-K56 acetylation (H3K56Ac) enhances these turnover events and promotes nucleosome assembly during S phase. Here we sequence nascent transcripts to …
CBP/p300-mediated acetylation of histone H3 on lysine 56 | Nature
Mar 8, 2009 · Acetylation within the globular core domain of histone H3 on lysine 56 (H3K56) has been shown to have a critical role in packaging DNA into chromatin during DNA replication …
H3K56 deacetylation and H2A.Z deposition are required for …
Apr 22, 2022 · Importantly, genome-wide analyses demonstrated the general roles of H3K56 deacetylation and H2A.Z deposition in aberrant spreading of heterochromatin. Together, our …
CBP/p300 介导的组蛋白 H3 在赖氨酸 56 上的乙酰化,Nature - X-MOL
Mar 8, 2009 · 最近表明，赖氨酸 56 (h3k56) 上的组蛋白 h3 球状核心域内的乙酰化在 dna 复制和修复后将 dna 包装成染色质方面具有关键作用。
Histone H3 Lysine 56 Methylation Regulates DNA ... - ScienceDirect
Apr 13, 2012 · We now report the presence of H3K56 monomethylation (H3K56me1) in mammalian cells and find that the histone lysine methytransferase G9a/KMT1C is required for …
Molecular dynamics simulations reveal how H3K56 acetylation …
Nov 1, 2021 · H3K56ac induces the nearby DNA to bulge away from the H3 histone and it distorts the H3 αN helix. H3K56ac causes more DNA exposure when it is damaged by a benzo …
Acetylation of H3K56 orchestrates UV-responsive chromatin …
May 1, 2022 · H3K56 acetylation is essential for conferring DNA accessibility during NER. Recruitment of NER factor Rad16 post UV is H3K56 acetylation dependent. H3K56 acetylation …