H3K9me3 - Wikipedia
H3K9me3 is an epigenetic modification to the DNA packaging protein Histone H3. It is a mark that indicates the tri-methylation at the 9th lysine residue of the histone H3 protein and is often …
The Emerging Role of H3K9me3 as a Potential Therapeutic Target …
Histone 3 lysine 9 trimethylation (H3K9me3) is a post-translational modification known to be involved in the regulation of a broad range of biological processes, including the formation of …
Establishment of H3K9-methylated heterochromatin and its
May 13, 2021 · Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9 (H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …
Distinct H3K9me3 heterochromatin maintenance dynamics …
Oct 31, 2024 · H3K9me3 heterochromatin, established by lysine methyltransferases (KMTs) and compacted by heterochromatin protein 1 (HP1) isoforms, represses alternative lineage genes …
The control of gene expression and cell identity by H3K9 …
Histone 3 lysine 9 trimethylation (H3K9me3) is a conserved histone modification that is best known for its role in constitutive heterochromatin formation and the repression of repetitive …
TNRC18 engages H3K9me3 to mediate silencing of endogenous …
Nov 8, 2023 · Collectively, we describe a new H3K9me3-sensing and regulatory pathway that operates to epigenetically silence evolutionarily young ERVs and exert substantial effects on …
Role of H3K9me3 heterochromatin in cell identity establishment …
The ability of H3K9me3 to influence cell identity challenges the original concept of H3K9me3-marked heterochromatin as mainly a constitutive type of chromatin and provides a further level …
H3K9 methylation regulates heterochromatin silencing through
Jun 26, 2024 · Histone H3 lysine-9 methylation (H3K9me) is a hallmark of the condensed and transcriptionally silent heterochromatin. It remains unclear how H3K9me controls transcription …
Frontiers | The Emerging Role of H3K9me3 as a Potential …
Aug 1, 2019 · Histone 3 lysine 9 trimethylation (H3K9me3) is a post-translational modification known to be involved in the regulation of a broad range of biological processes, including the …
The silent guardian: unraveling the roles of H3K9me3 in genome ...
Jul 2, 2024 · In this review, we provide a comprehensive summary of the multifaceted roles of H3K9me3, a histone mark associated with silent chromatin, in DNA damage repair and …