Establishment of H3K9-methylated heterochromatin and its
2021年5月13日 · Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9 (H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …
Regulation of mammalian 3D genome organization and histone …
2021年5月13日 · Histone H3 lysine 9 dimethylation (H3K9me2) is a highly conserved silencing epigenetic mark. Chromatin marked with H3K9me2 forms large domains in mammalian cells …
H3K9me selectively blocks transcription factor activity and ensures ...
2021年11月4日 · Gasser and colleagues report that H3K9me2 and H3K9me3 repress lineage-specific and germline genes by restricting the activity of a subset of transcription factors in …
H3K9me2 orchestrates inheritance of spatial positioning of …
Here we show that histone 3 lysine 9 dimethylation (H3K9me2) is an evolutionarily conserved, specific mark of nuclear peripheral heterochromatin and that it is retained through mitosis. …
DNA methylation underpins the epigenomic landscape regulating …
2022年9月20日 · Non-CG methylation and H3K9me2 reinforce each other through a feedback loop: methylated CHG and CHH recruit the H3K9-specific methyltransferases SUVH4, …
Writing and Reading Histone H3 Lysine 9 Methylation in
2020年5月6日 · In this review, we summarize work from the recent studies regarding the regulation of H3K9me2, emphasizing the process of deposition and reading and the biological …
H3K9me2 orchestrates inheritance of spatial positioning of …
2019年10月1日 · The H3K9me2 modification of peripheral heterochromatin ensures that positional information is safeguarded through cell division such that individual LADs are re …
H3K9 methylation regulates heterochromatin silencing through
2024年6月26日 · Histone H3 lysine-9 methylation (H3K9me) is a hallmark of the condensed and transcriptionally silent heterochromatin. It remains unclear how H3K9me controls transcription …
G9a/GLP-sensitivity of H3K9me2 Demarcates Two Types of …
2020年8月1日 · Here, we investigated the functional roles of H3 lysine 9 dimethylation (H3K9me2), one of the abundant histone modifications, in three-dimensional (3D) genome …
Abo1 is required for the H3K9me2 to H3K9me3 transition in ...
2020年4月8日 · In 2017, a study in S. pombe revealed that H3K9me2 and H3K9me3 have distinct roles in gene silencing, with H3K9me2 being permissive for transcription 22. Our work …
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