H3K4me3 is an epigenetic modification to the DNA packaging protein Histone H3 that indicates tri-methylation at the 4th lysine residue of the histone H3 protein and is often involved in the regulation of gene expression. [1]

2023年3月1日 · Our data show that H3K4me3 has a key role in regulating RNAPII pause-release; however, notably, we did not detect a role for H3K4me3 in regulating transcription initiation. Models to study...

H3K4me3是组蛋白H3第四位赖氨酸在甲基转移酶 (HMT) 催化下发生三甲基化。 H3K4me3是最重要的甲基化修饰之一，真核生物中该修饰在转录起始位点普遍发生，通常在基因的启动子附近富集，并且与基因的转录相关，是表观遗传学一个标志，其水平可以反映出转录的程度，在基因的转录中有着重要的作用。 H3K4me3书写器、擦除器和阅读器. 组蛋白的PTM是表观遗传机制的关 …

2024年6月21日 · Trimethylated H3 lysine 4 (H3K4me3) is one of the most studied histone modifications owing to its enrichment at the start sites of transcription and its association with gene expression and processes determining cell fate, development, and disease.

2022年5月6日 · Here, we show that mcm2-3A and dpb3 ∆ mutant cells markedly reduce the asymmetric distribution of H3K4me3 during cell cycle progression before mitosis.

2024年6月21日 · Trimethylated H3 lysine 4 (H3K4me3) is one of the most studied histone modifications owing to its enrichment at the start sites of transcription and its association with gene expression and processes determining cell fate, development, and disease.

Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to mark the transcription start sites of active genes. Here, we show that H3K4me3 domains that spread more broadly over genes in a given cell type preferentially mark genes that are essential for the identity and function of that cell type.

Tri-methylation of lysine 4 on histone H3 (H3K4me3) is a near-universal chromatin modification at the transcription start site of active genes in eukaryotes from yeast to man and its levels reflect the amount of transcription.

Based on H3K4me3, H3K9ac, H3K27ac, H3K27me3 and H3K9me3 histone tags, respectively, we investigated 25,075 human genes and 3121 molecular pathways.

In this report, we performed chromatin immunoprecipitation-sequencing (ChIP-Seq) to identify the genome-wide regions that undergo changes in histone H3 Lysine 4 trimethylation (H3K4me3) occupancy in response to TGFβ stimulation.