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H3K27me3 - Pathology Outlines
Mar 21, 2023 · H3K27me3 is reported to rarely be lost in a subset of other tumors, such as meningioma, radiation associated unclassified sarcoma, radiation associated angiosarcoma, undifferentiated pleomorphic sarcoma, osteosarcoma, dedifferentiated chondrosarcoma, melanoma and Merkel cell carcinoma (Pathol Res Pract 2018;214:417, Mod Pathol 2016;29:4 ...
Malignant peripheral nerve sheath tumor (MPNST)
Jan 20, 2021 · Loss of nuclear H3K27me3 in high grade sporadic and radiation associated tumors Sensitivity is lower in low grade and NF1 associated MPNST (complete loss in 88/122 (72%) and mosaic / partial loss in 23/122 (19%), loss of expression in 47/68 tumors (69%)) (Mod Pathol 2017;30:1677, Am J Surg Pathol 2016;40:479)
Pathology Outlines - Ependymoma overview
Dec 3, 2024 · H3K27me3. The H3K27 trimethylation status distinguishes PFA from PFB. PFA has loss of the H3K27 trimethylation and therefore loss of nuclear staining on H3K27me3 staining, while PFB group ependymoma tumor cells have retained nuclear expression. Answers A, C, D and E are incorrect because they do not distinguish H3K27 trimethylation status ...
Pathology Outlines - MDM2
Nov 25, 2020 · Focal / weak / moderate (10%) or strong (26%) IHC staining corresponding to polysomy / weak gain / weak amplification (34%) or high level amplification (1.5%) by FISH (H3K27me3 IHC recommended instead) (Am J Surg Pathol 2018;42:656) Angiosarcoma (Cardiovasc Pathol 2019;43:107142)
Pathology Outlines - Soft tissue
Soft tissue stains: AE1 / AE3 ALK1 BCOR beta catenin caldesmon CAMTA1 CCNB3 (pending) CD31 CD34 CD99 CDK4 D2-40 DDIT3 (pending) desmin DOG1 DUX4 EBER EMA ERG ETV4 (pending) factor XIIIa FLI1 FOSB (pending) GLUT1 H3K27me3 HHV8 / LANA1 HMB45 c-kit / CD117 MDM2 MelanA MUC4 MYOD1 myogenin NKX2.2 (pending) NKX3.1 NR4A3 (pending) …
Pathology Outlines - Inhibin
Inhibin alpha protein expression is generally considered an important diagnostic feature for adrenocortical tumors and sex cord stromal tumors of the testis and the ovary (Biomedicines 2022;10:2507)
Pathology Outlines - Mucinous cystadenoma and adenofibroma
Sep 28, 2021 · Mucinous tumor with focal atypia / proliferation (Hum Pathol 2004;35:949, Hum Pathol 2004;35:918, Am J Surg Pathol 1991;15:227):
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Aug 9, 2024 · H3K27me3: loss or reduced expression in a subset of postradiation angiosarcomas (Histopathology 2021;79:836, Virchows Arch 2018;472:361) ER / PR / HER2 Electron microscopy description
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Oligodendroglioma, IDH mutant and 1p / 19q codeleted
Apr 25, 2022 · Oligodendroglioma, IDH mutant and 1p/19q codeleted is a diffusely infiltrating glial neoplasm with IDH1 or IDH2 mutation and 1p / 19q whole arm codeletion