2023年10月31日 · Loss of H3K27 trimethylation (H3K27me3) by IHC predicts poor prognosis in grade 1 and 2 meningiomas but not grade 3 (Acta Neuropathol 2018;135:955) TERT promoter mutation is seen in high grade meningioma progressed from low grade, not in primary atypical meningioma (Brain Pathol 2014;24:184)

2023年9月19日 · Loss of nuclear H3K27me3 in high grade sporadic and radiation associated tumors Sensitivity is lower in low grade and NF1 associated MPNST (complete loss in 88/122 (72%) and mosaic / partial loss in 23/122 (19%), loss of expression in 47/68 tumors (69%)) (Mod Pathol 2017;30:1677, Am J Surg Pathol 2016;40:479)

2024年12月3日 · H3K27me3. The H3K27 trimethylation status distinguishes PFA from PFB. PFA has loss of the H3K27 trimethylation and therefore loss of nuclear staining on H3K27me3 staining, while PFB group ependymoma tumor cells have retained nuclear expression. Answers A, C, D and E are incorrect because they do not distinguish H3K27 trimethylation status ...

4 天之前 · Loss of nuclear H3K27me3 in high grade and radiation associated tumors Loss of INI1 can be seen in epithelioid MPNSTs Perineurioma: S100-, EMA+, claudin1+, GLUT1+ Nonencapsulated, well demarcated spindle cell tumor composed of cells with a slender, fibroblast-like appearance with long, delicate cytoplasmic processes

90% are sporadic, with no established risk factors other than smoking in a subset of cases that harbor mutation signatures typical of smoking and mismatch repair deficiency (J Intern Med 2002;252:206, Cancer Cell 2016;29:723)

4 天之前 · Focal / weak / moderate (10%) or strong (26%) IHC staining corresponding to polysomy / weak gain / weak amplification (34%) or high level amplification (1.5%) by FISH (H3K27me3 IHC recommended instead) (Am J Surg Pathol 2018;42:656) Angiosarcoma (Cardiovasc Pathol 2019;43:107142)

2022年11月3日 · Independent predictor of improved overall survival and progression free survival in neuroendocrine tumors (NET) (Pancreas 2016;45:1386, Eur J Nucl Med Mol Imaging 2017;44:468, Medicine (Baltimore) 2015;94:e1281)

PathologyOutlines.com, free, updated outline surgical pathology clinical pathology pathologist jobs, conferences, fellowships, books

2020年11月5日 · Loss of H3K27me3 expression has good sensitivity and robust specificity for the diagnosis of MPNST; however, H3K27me3 expression is retained in epithelioid MPNST (Am J Surg Pathol 2016;40:479, Histopathology 2017;70:385)

Inhibin alpha protein expression is generally considered an important diagnostic feature for adrenocortical tumors and sex cord stromal tumors of the testis and the ovary (Biomedicines 2022;10:2507)