Eukaryotic peptide chain release factor GTP-binding subunit ERF3A is an enzyme that in humans is encoded by the GSPT1 gene. [5] [6] [7]

2024年12月25日 · GSPT1 (G1 To S Phase Transition 1) is a Protein Coding gene. Diseases associated with GSPT1 include Duane-Radial Ray Syndrome and Myelodysplastic Syndrome . Among its related pathways are Peptide chain elongation and Nervous system development .

2021年8月20日 · GSPT1 (G1 to S phase transition 1) is a translation termination factor that recognizes the termination codon by binding eRF1, forcing the proteins to dissociate from the ribosome after...

This review aims to introduce current understanding of antitumor mechanism of molecular glues targeting GSPT1, summarize pharmacology profiles of existing molecular glues, and outline development strategies of novel molecular glues.

2024年2月1日 · Molecular glue targeting GSPT1 is an innovative antitumor agent, which induces degradation of GSPT1 and affects proliferation, migration, and invasion of various tumor cells. In clinical trial studies, positive efficacy responses were observed in patients who received injections of CC-90009 or orally administered of MRT-2359.

2024年8月8日 · We previously reported that G1 to S phase transition 1 (GSPT1) depletion induces delayed cell cycle in primary astrocytes. Herein, we examined the potential of GSPT1 as a novel target for...

Studied demonstrated that GSPT1 plays a vital role in the acute myeloid leukemia (AML) and MYC-driven lung cancer. Thus, molecular glue (MG) degraders targeting GSPT1 is a novel and promising approach for treating AML and MYC-driven cancers.

Identification of GSPT1 as prognostic biomarker and promoter of malignant colon cancer cell phenotypes via the GSK-3beta/CyclinD1 pathway. miR-27b-3p suppresses gastric cancer cell proliferation, invasion, and migration via negative expression regulation of GSPT1.

2022年8月15日 · We identified the domains of GSPT1 essential for cell survival and show that GSPT1 degradation leads to impaired translation termination, activation of the integrated stress response pathway, and TP53-independent cell death.

2024年8月21日 · GSPT1, a small GTPase, collaborates with the translation termination factor eRF1 to facilitate the concluding stage of protein biosynthesis, namely, translation termination . When GSPT1 is degraded by CC-885, it leads to wide-spectrum growth inhibition in patient-derived AML and cancer cell lines.