炎症因子的表达调控是炎症反应的关键步骤，与自身免疫疾病以及癌症等密切相关．一氧化氮(nitric oxide，NO)在炎症因子表达调控中具有重要作用，但已有的研究多关注于NO合成对炎症因子的调控作用，而对NO代谢的作用知之甚少．亚硝基化谷胱甘 肽还原酶(S ...

GSNOR modulates reactive nitric oxide (•NO) availability in the cell by catalyzing the breakdown of GSNO, and indirectly regulates S-nitrosothiols (RSNOs) through GSNO-mediated protein S-nitrosation. The dysregulation of GSNOR can significantly alter cellular homeostasis, leading to …

该研究发现了心肌肥厚中调控MLP巯基亚硝基化修饰的酶是谷胱甘肽还原酶(S-nitrosoglutathione reductase, GSNOR)。 GSNOR是一种去巯基亚硝基化修饰蛋白，在心肌肥厚时，其表达降低促进靶蛋白巯基亚硝基化修饰水平增加，促进心肌肥厚。 以往认为GSNOR主要是一种定位于胞浆的蛋白质，通过利用GSNOR心肌特异性敲除小鼠构建心肌重构模型时发现GSNOR敲除会显著加重线粒体功能和结构紊乱，但是其线粒体的调控作用及方式仍不清楚。

GSNOR modulates reactive nitric oxide (•NO) availability in the cell by catalyzing the breakdown of GSNO, and indirectly regulates S-nitrosothiols (RSNOs) through GSNO-mediated protein S-nitrosation. The dysregulation of GSNOR can significantly alter cellular homeostasis, leading to …

We are studying the enzyme S-nitrosoglutathione reductase (GSNOR), originally identified in plants and other organisms as formaldehyde dehydrogenase (FALDH), a type III alcohol dehydrogenase. Using mutants of GSNOR in Arabidopsis (hot5 mutants), we have shown that GSNOR is ciritical to nitric oxide homeostasis.

2023年7月5日 · 该论文首次发现GSNOR在心肌细胞线粒体定位，并明确线粒体GSNOR（谷胱甘肽还原酶，S-nitrosoglutathione reductase）通过调控线粒体蛋白ANT1（腺嘌呤核苷酸转位酶1，ADP/ATP translocase 1）的巯基亚硝基化修饰影响线粒体功能，参与心肌重构和心衰进程。...

2024年4月3日 · Our findings suggested that GSNOR is a regulator of the NLRP3 inflammasome and that reducing the level of S -nitrosylated MAPK14 may constitute an effective strategy for alleviating diseases...

gsnor 代谢 s-亚硝基谷胱甘肽 (gsno)、s-羟甲基谷胱甘肽（甲醛和谷胱甘肽的自发加合物）和一些醇。 GSNOR 通过催化 GSNO 的分解来调节细胞中反应性一氧化氮 (•NO) 的可用性，并通过 GSNO 介导的蛋白质 S-亚硝化作用间接调节 S-亚硝基硫醇 (RSNO)。

2022年1月11日 · Herein, we show that the ganoderic acid (GA) content in GSNOR-silenced (GSNORi) strains is significantly lower (by 25%) than in wild type (WT) under heat stress (HS). Additionally, silencing...

2023年7月6日 · 季勇教授团队首次发现GSNOR的线粒体定位并揭示线粒体GSNOR在心力衰竭中的重要保护作用。 6月28日，哈尔滨医科大学寒地心血管病全国重点实验室季勇教授团队首次发现GSNOR的线粒体定位并揭示线粒体GSNOR在心力衰竭中的重要保护作用，研究成果论文《Mitochondrial GSNOR Alleviates Cardiac Dysfunction via ANT1 Denitrosylation》发表在Circulation Research (IF=20.1)。

2022年8月11日 · 该研究利用 S-亚硝基化谷胱甘肽还原酶（ S-nitrosoglutathione reductase, GSNOR ）基因敲除小鼠，在 1-甲基-4-苯基-1,2,3,6-四氢吡啶（ 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ， MPTP ）诱导的帕金森病（ Parkinson’s disease, PD ）模型中，阐明了 GSNOR 通过调控细胞周期蛋白依赖激酶 5 ...

2021年2月1日 · In this review, we focus on the emerging role of GSNOR as a master regulator in oxidative stress through its regulation of the interaction of ROS, RNS, and Fe, and highlight recent discoveries in post-translational modifications of GSNOR and functional variations of natural GSNOR variants during oxidative stress.

该论文首次发现 E3泛素酶 神经元前体细胞表达发育下调4（Neuronal precursor cell expressed developmentally down-regulated 4，NEDD4）介导谷胱甘肽还原酶（S-nitrosoglutathione reductase，GSNOR）的泛素化-蛋白酶体降解 ，导致其表达水平降低，加重 心肌肥厚 ；并发现了两种NEDD4活性 ...

2024年4月7日 · 近期，国际知名期刊Cellular and Molecular Immunology发表了中国科学院昆明动物研究所姚永刚团队题为GSNOR negatively regulates the NLRP3 inflammasome via S-nitrosation of MAPK14的研究论文。 该研究发现GSNOR可通过降低MAPK14蛋白亚硝基化修饰，进而抑制其活性，并在转录水平上调控NLRP3和IL-1β表达。 NLRP3炎症小体由胞内固有免疫受体NLRP3、接头蛋白ASC和蛋白酶caspase-1（半胱氨酸天冬氨酸蛋白酶1）组成，形成了一个多蛋白复合物。

2024年6月18日 · 该研究利用S-亚硝基化谷胱甘肽还原酶（S-nitrosoglutathione reductase,GSNOR）基因敲除小鼠和神经元中过表达GSNOR的小鼠，建立吗啡诱导的镇痛耐受小鼠模型，阐明了GSNOR通过调控蛋白激酶C（Protein kinase C-α，PKCα）的亚硝基化，影响PKCα的激酶活性，进而参与吗啡镇痛 ...

2017年4月10日 · GSNOR modulates reactive nitric oxide (•NO) availability in the cell by catalyzing the breakdown of GSNO, and indirectly regulates S-nitrosothiols (RSNOs) through GSNO-mediated protein S-nitrosation. The dysregulation of GSNOR can significantly alter cellular homeostasis, leading to disease.

2019年6月28日 · SPL-334是一种有效的选择性S-亚硝基谷胱甘肽还原酶(GSNOR)抑制剂。SPL-334导致气道中Th2细胞因子IL-5和IL-13的产生以及趋化因子CCL11(eotaxin-1)的水平显著降低。SPL-334可用于过敏性气道炎症的研究[1]。

GSNOR inhibition (GSNOR −/− iPSCs) expedites the epithelial-mesenchymal transition (EMT) and promotes cardiomyocyte progenitor cell proliferation, differentiation, and migration. These findings are consistent with emerging roles for protein S-nitrosylation in developmental biology (including cardiomyocyte development), aging/longevity, and ...

In this review, we focus on the emerging role of GSNOR as a master regulator in oxidative stress through its regulation of the interaction of ROS, RNS, and Fe, and highlight recent discoveries in post-translational modifications of GSNOR and functional variations of natural GSNOR variants during oxidative stress.

Here, we found that S-nitrosoglutathione reductase (GSNOR), the key enzyme that metabolizes intracellular nitric oxide (NO) and regulates S-nitrosation, was significantly increased in the hippocampus of both aging humans and mice.