
Glutathione peroxidase 4 - Wikipedia
GPX4 is a phospholipid hydroperoxidase that protects cells against membrane lipid peroxidation. GPX4 was first discovered in biochemistry laboratories of the University of Padua, where it was described as an enzyme capable of protecting against peroxidation.
GPX4 Gene - GeneCards | GPX4 Protein | GPX4 Antibody
2024年12月25日 · GPX4 (Glutathione Peroxidase 4) is a Protein Coding gene. Diseases associated with GPX4 include Spondylometaphyseal Dysplasia, Sedaghatian Type and Bone Disease. Among its related pathways are Biosynthesis of specialized proresolving mediators (SPMs) and Fatty acid metabolism.
The Selenoprotein Glutathione Peroxidase 4: From Molecular …
Several recent studies have provided insights into how GPX4 is distinguished from the rest of the glutathione peroxidase family, the unique biochemical properties of GPX4, how GPX4 is related to lipid peroxidation and ferroptosis, and how the enzyme may be modulated as a potential therapeutic target.
Deciphering the role of the MALT1-RC3H1 axis in regulating GPX4 protein ...
2025年1月7日 · Through FACS-based genome-wide CRISPR screening, we identified MALT1 as a regulator of GPX4 protein. Inhibition of MALT1 expression enhances GPX4 ubiquitination-mediated degradation by up-regulating the E3 ubiquitin ligase RC3H1.
GPX4 protein expression summary - The Human Protein Atlas
Number of protein-coding transcripts from the gene as defined by Ensembl. A summary of the overall protein expression profile across the analyzed normal tissues based on knowledge-based annotation, presented in the Tissue resource. "Estimation of protein expression could not be performed. View primary data."
GPX4 glutathione peroxidase 4 [ Homo sapiens (human) ]
2025年2月9日 · The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage.
GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment
2023年5月1日 · Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of ferroptosis, which takes role in the lipid and amine acid metabolism and influences the cell aging, oncogenesis, and cell death.
mTORC1 couples cyst(e)ine availability with GPX4 protein
2021年3月11日 · We show that pharmacologic inhibition of mTORC1 decreases GPX4 protein levels, sensitizes cancer cells to ferroptosis, and synergizes with ferroptosis inducers to suppress patient-derived...
2879 - Gene ResultGPX4 glutathione peroxidase 4 [ (human)]
Glutathione peroxidase is a moonlighting protein that functions both as a peroxidase as well as a structural protein in mature spermatozoa. GPx4, through effects on AIF, plays a major role in maintaining the oxidative phosphorylation system and …
GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment
2023年5月1日 · Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of ferroptosis, which takes role in the lipid and amine acid metabolism and influences the cell aging, oncogenesis, and cell death.