Dec 25, 2024 · GPR31 (G Protein-Coupled Receptor 31) is a Protein Coding gene. Diseases associated with GPR31 include Ischemia and Vulvar Dystrophy . Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors) .

Jan 23, 2019 · Mice that lack GPR31, which was highly and selectively expressed in intestinal CX3CR1 + cells, showed defective dendrite protrusions of CX3CR1 + cells in the small intestine.

Title: The G protein-coupled receptor GPR31 promotes membrane association of KRAS. The data implicate 12-HETER1 in a critical new role in the regulation of prostate cancer progression and offer a novel alternative target for therapeutic intervention.

Dec 3, 2020 · GPR31 (G-protein–coupled receptor 31) regulates PAR (protease-activated receptor)-4–mediated platelet activation resulting in orchestrated control of Rap1-RASA3–mediated α IIb β 3 activation.

We cloned and identified GPR31, a plasma membrane orphan G protein-coupled receptor that displays high affinity for the human 12-lipoxygenase-derived product 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (HETE). Thus, GPR31 is named 12 …

Dec 11, 2017 · Here, using integrative 'omics' analysis, we identified an arachidonate 12-lipoxygenase (ALOX12)–12-hydroxyeicosatetraenoic acid (12-HETE)–G-protein-coupled receptor 31 (GPR31) signaling axis as...

Gene ID: 2853, updated on 8-Feb-2025. Enables G protein-coupled receptor activity and arachidonate binding activity. Involved in G protein-coupled receptor signaling pathway and response to acidic pH. Located in plasma membrane. [provided by Alliance of Genome Resources, Feb 2025]

Mar 5, 2024 · 12-HETER1/GPR31, a high-affinity 12 (S)-hydroxyeicosatetraenoic acid receptor, is significantly up-regulated in prostate cancer and plays a critical role in prostate cancer progression. Telomere length correlates with subtelomeric DNA methylation in long-term mindfulness practitioners.

GPR31 is a G i-coupled receptor expressed in platelets, which signals through 12(S)-HETE to potentiate plate-let aggregation, calcium flux, and dense granule release through the PAR4 thrombin receptor. We discovered that GPR31 and PAR4 form a stable heterodimer complex and provide evidence that GPR31/PAR4 functions in

These findings demonstrate that lactate and pyruvate, which are produced in the intestinal lumen in a bacteria-dependent manner, contribute to enhanced immune responses by inducing GPR31-mediated dendrite protrusion of intestinal CX3CR1 + cells.