2024年12月25日 · GPR183 (G Protein-Coupled Receptor 183) is a Protein Coding gene. Diseases associated with GPR183 include Bile Acid Synthesis Defect, Congenital, 3 and Trichothiodystrophy 7, Nonphotosensitive. Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors).

2023年3月9日 · Loss-of-function mutation of Gpr183 or treatment with a GPR183 antagonist reduced macrophage infiltration and inflammatory cytokine production in the lungs of IAV- or SARS-CoV-2-infected mice. The GPR183 antagonist significantly attenuated the severity of SARS-CoV-2 infection and viral loads.

2023年4月4日 · GPR183 is a GPCR for oxysterol ligands, including 7α,25-OHC, and mediates the migration of various immune cells and their proper positioning in lymphoid tissues.

2024年8月23日 · GPR183 (G protein-coupled receptor 183), a recently identified G protein-coupled receptor for oxysterols and hydroxylated metabolites of cholesterol, has pleiotropic roles in lipid metabolism and immune responses. However, the role of GPR183 in the regulation of endothelial function remains unknown.

GPR183 Regulates Interferons, Autophagy, and Bacterial Growth During Mycobacterium tuberculosis Infection and Is Associated With TB Disease Severity. Orphan G-protein coupled receptor 183 (GPR183) potentiates insulin secretion …

2015年9月11日 · Here, we show that G protein-coupled receptor 183 (Gpr183) signaling serves as an indispensable switch for HSPC emergence by repressing Notch signaling before the onset of EHT. Inhibition...

2020年11月5日 · We show here that GPR183 is a key regulator of intracellular bacterial growth and type-I IFN production during mycobacterial infection and reduced GPR183 expression is associated with increased TB disease severity.

Our findings show that eosinophils are among the earliest cells from circulation to sense and respond to Mtb infection of alveolar macrophages and reveal a role for GPR183 in the migration of eosinophils into lung tissue. Eosinophils are usually associated with allergy or type II responses.

The G protein‐coupled receptor GPR183/EBI2, which is activated by oxysterols, is a therapeutic target for inflammatory and metabolic diseases where both antagonists and agonists are of potential interest.

2023年12月4日 · In this study, we discovered a highly potent GPR183 antagonist, compound 32, with good aqueous solubility, excellent selectivity, and pharmacokinetic properties. Meanwhile, compound 32 showed exceptional efficacy for rheumatoid arthritis (RA) disease in a mouse collagen-induced arthritis (CIA) model, with an efficacious dose of 0.1 mg/kg.