Gorlin syndrome — also called basal cell nevus syndrome, nevoid basal cell carcinoma syndrome (NBCCS) and Gorlin-Goltz syndrome — is a rare genetic disorder that increases your risk of developing cancerous and benign (noncancerous) tumors.

2023年8月8日 · Gorlin syndrome, also called Gorlin-Goltz syndrome, basal cell nevus syndrome (BCNS), or nevoid basal cell carcinoma syndrome, is an autosomal dominant familial cancer syndrome. It is characterized by numerous basal cell carcinomas (BCCs), along with skeletal, ophthalmologic, and neurologic abnormalities.

First described in 1960 by Gorlin and Goltz, [5] NBCCS is an autosomal dominant condition that can cause unusual facial appearances and a predisposition for basal-cell carcinoma, a type of skin cancer which rarely spreads to other parts of the body. The prevalence is reported to be 1 case per 56,000–164,000 population.

The risk for ovarian tumors and skin cancer is increased with basal cell nevus syndrome (also called Gorlin syndrome or nevoid basal cell carcinoma), a rare autosomal dominant cancer genetic syndrome.

2024年9月20日 · Nevoid basal cell carcinoma syndrome (NBCCS; MIM #109400) is a rare, autosomal dominant, tumor-predisposing disorder caused by germline pathogenic variants in the human homolog of the patched (PTCH1) gene .

Gorlin syndrome occurs when the PTCH1, PTCH2, or the SUFU gene is not working correctly. It is inherited in an autosomal dominant manner. Gorlin syndrome is diagnosed based on clinical examination for specific features and genetic testing.

Gorlin syndrome, also known as nevoid basal cell carcinoma syndrome, is a condition that increases the risk of developing various cancerous and noncancerous tumors. Explore symptoms, inheritance, genetics of this condition.

2024年1月24日 · Nevoid basal cell carcinoma syndrome (NBCCS) is a rare genetic disorder characterized by a variety of developmental abnormalities and predisposition to cancer, particularly basal cell carcinoma of the skin. The specific symptoms and severity of NBCCS can vary greatly from one individual to another, even among members of the same family.

2002年6月20日 · Nevoid basal cell carcinoma syndrome (NBCCS) is characterized by the development of multiple jaw keratocysts, frequently beginning in the second decade of life, and/or basal cell carcinomas (BCCs), usually from the third decade onward.

2023年8月8日 · Gorlin syndrome is also called naevoid basal cell carcinoma syndrome. Around 80 out of every 100 people (around 80%) with the syndrome develop multiple basal cell cancers of the skin . The cancers usually start to develop around the age of 30. But they can develop in younger people.