2024年6月12日 · Authors investigated GLUT9, crucial for urate reabsorption, and determined its structure with urate and apigenin providing insight for substrate preference and rational drug design.

2019年2月24日 · GLUT9是目前研究血尿酸代谢最热门的基因，主要在肝肾等组织表达。 研究发现，GLUT9对尿酸的转运是正常对照组的31倍，是URAT1组的7倍。 研究人员还对比了GLUT9缺乏和URAT1缺乏患者的血尿酸水平，结果发现：URAT1缺失的患者，尿酸排泄比正常组高出40%到90%；而GLUT9缺失的患者，尿酸排泄比正常组高出150%。 以上研究表明，GLUT9在尿酸的重吸收上，发挥着比URAT1更为重要的作用。 2、尿酸分泌转运蛋白（可以把它看成一张网，网眼 …

2024年6月13日 · GLUT9 的 N 末端序列在蛋白质表达运输中起着关键作用：氨基末端缺失的 GLUT9 (GLUT9ΔN) 靶向肾小管中的顶膜，是负责将尿酸盐从肾小管腔重吸收到细胞中的主要转运蛋白之一；然而全长序列的GLUT9 主要位于基底外侧膜上，是负责尿酸盐从细胞流出到血液中的 …

2023年6月13日 · A novel anti-hyperuricemic agent inhibiting GLUT9 may provide a new treatment option for the unmet medical needs of patients with CKD, particularly those with ‘urate underexcretion’ type ...

GLUT9 (glucose transporter 9) 的编码基因为SLC2A9 ,有两种剪切变异体:长型异构体(GLUT9L)和短型异构体(GLUT9S),主要分布于肝脏、肾脏和胎盘,在小肠和结肠几个组织中表达水平较低。

2022年2月11日 · Glucose transporter 9 (GLUT9) is a high-capacity uric acid transporter. The aim of this study was to investigate the placental uric acid transport system, and to identify the (sub-) cellular localization of GLUT9.

Here, we investigated the role of the recently identified urate transporter, Glut9, in the physiological control of urate homeostasis using mice with systemic or liver-specific inactivation of the Glut9 gene. We show that Glut9 is expressed in the basolateral membrane of hepatocytes and in both apical and basolateral membranes of the distal ...

Solute carrier family 2, facilitated glucose transporter member 9 is a protein that in humans is encoded by the SLC2A9 gene. [5][6][7] This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a …

Glucose transporter 9 (GLUT9), which transports urate in an electrogenic and voltage-dependent manner, plays an important role in the maintenance of normal blood uric acid/urate levels. In the present study, we established a cell model based on …

GLUT9 is a novel, facilitative glucose transporter isoform that exists as two alternative splice variants encoding two proteins that differ in their NH2-terminal sequence (GLUT9a and GLUT9b). Both forms of GLUT9 protein and mRNA are expressed in the ...