Glyoxalase I is an attractive target for the development of drugs to treat infections by some parasitic protozoa, and cancer. Several inhibitors of glyoxalase I have been identified, such as …

2024年12月25日 · GLO1 (Glyoxalase I) is a Protein Coding gene. Diseases associated with GLO1 include Pulmonary Tuberculosis and Hyperglycemia. Among its related pathways are …

Glyoxalase I (GLO1), glyoxalase II (GLO2), and reduced glutathione (GSH). In bacteria, there is an additional enzyme that functions if there is no GSH, it is called the third glyoxalase protein, …

2020年11月1日 · GLO1 is a key rate-limiting enzyme in the glyoxalase system and it is linked to diabetes, cardiovascular disease, neurodegenerative disorders, and multidrug resistance in …

2012年11月18日 · Glyoxalase 1 (GLO1) is a ubiquitous cellular enzyme that participates in the detoxification of methylglyoxal (MG), a cytotoxic byproduct of glycolysis that induces protein …

In this review, we discuss the role of Glo1 in the malignant progression of cancer and its possible use as a promising therapeutic target for tumor therapy. We also summarize therapeutic …

Glo1 is involved in the Min-U-Sil 5 crystalline silica-induced BEAS-2B cell mitochondrial apoptotic pathway. Two classes of the metalloenzyme GlxI exist and vary in their metal dependencies; …

2020年2月15日 · Glyoxalase I (GLO1) is a homodimeric Zn 2+-metalloenzyme that catalyses the transformation of methylglyoxal (MG) to d-lacate through the intermediate S-d …

2025年2月8日 · Glyoxalase I reduces glycative and oxidative stress and prevents age-related endothelial dysfunction through modulation of endothelial nitric oxide synthase …

Glyoxalase I (GLO1), a methylglyoxal detoxification enzyme, is implicated in the progression of human malignancies. The role of GLO1 in gastric cancer development or progression is …