GIPC is an acronym for "GAIP Interacting Protein C-terminus". RGS proteins are "Regulators of G protein Signaling" and RGS-GAIP is a "GTPase Activator protein for Gαi/Gαq", which are two major subtypes of Gα proteins.

Dec 25, 2024 · GIPC1 (GIPC PDZ Domain Containing Family Member 1) is a Protein Coding gene. Diseases associated with GIPC1 include Oculopharyngodistal Myopathy 2 and Oculopharyngodistal Myopathy 1. Among its related pathways are Negative regulation of FGFR3 signaling and Signaling by TGFBR3.

Feb 8, 2025 · GIPC1 is a novel breast cancer-associated immunogenic antigen that is overexpressed in breast cancer; GIPC1 protein is overexpressed in ovarian and breast cancer; Targeting GIPC could be a promising new treatment option for pancreatic cancer. Observational study of gene-disease association. (HuGE Navigator)

GIPC1 is a cytoplasmic scaffold protein that interacts with numerous receptor signaling complexes, and emerging evidence suggests that it plays a role in tumorigenesis. GIPC1 is highly expressed in a number of human malignancies, including breast, ovarian, gastric, and …

Jan 1, 2021 · Here, we identified a novel SR-B1-interacting protein, GIPC1 (GAIP-interacting protein, C terminus 1) that interacts with SR-B1 and stabilizes SR-B1 by negative regulation of its proteasomal and lysosomal degradation pathways.

Here, we identified a novel SR-B1-interacting protein, GIPC1 (GAIP-interacting protein, C terminus 1) that interacts with SR-B1 and stabilizes SR-B1 by negative regulation of its proteasomal and lysosomal degradation pathways.

GGC repeat expansions in the 5'-UTR ranging from 73 to 164 were reported in patients, compared with a normal range from 12 to 32 in unaffected individuals. Patient skeletal muscle showed similar protein levels to those of unaffected individuals.

GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008 [PubMed 18775991]). [supplied by OMIM, Apr 2009]

gipc1是一种胞内支架蛋白，在细胞膜受体转运和调节中起重要作用，近年研究发现gipc1是一个新的肿瘤相关抗原和潜在的肿瘤治疗靶标。关于gipc1在肝癌发生发展中的作用及其分子机制尚不清楚。

GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008).[supplied by OMIM, Apr 2009]... show less