Gene isoform - Wikipedia
In genetics, gene isoforms are mRNAs that are produced from the same locus but are different in their transcription start sites (TSSs), protein coding DNA sequences (CDSs) and/or …
Protein isoform - Wikipedia
A protein isoform, or "protein variant", [1] is a member of a set of highly similar proteins that originate from a single gene and are the result of genetic differences. [2] While many perform …
Comprehensive identification of mRNA isoforms reveals the ... - Nature
2020年7月3日 · These genes produce alternative mRNA isoforms which remain poorly characterized, impeding understanding of how disease-associated mutations cause pathology. …
Human Isoform database
It is well established that different isoforms of a gene can exhibit different functions, and differential function is likely reflected by differential protein interactions. Cloning full-length …
Isoforms: Fundamental differences - eLife
2018年2月1日 · In other cases two or more closely related genes are responsible for the isoforms. At its simplest, isoform generation provides a mechanism to specialize the properties of a …
isoTarget: A Genetic Method for Analyzing the Functional Diversity …
(A) Introducing translational stops into alternative exons allows isoform-specific manipulations of the gene. Inserting the commonly used transcriptional stop cassette into an alternative exon …
Please explain what a gene isoform is in lay terms?
2017年4月13日 · Gene isoforms are all the different RNAs that can be synthesised from a single gene. You may be referring to splice variants, which are systems of getting different mRNAs …
A large-scale comparative study of isoform expressions measured …
Most eukaryotic genes produce different transcripts of multiple isoforms by inclusion or exclusion of particular exons. The isoforms of a gene often play diverse functional roles, and thus it is …
Assessing the functional relevance of splice isoforms
2021年5月22日 · Determining which transcripts produce biologically important isoforms is key to understanding isoform function and to interpreting the real impact of somatic mutations and …
Broad regulation of gene isoform expression by Wnt signaling in …
Differential gene isoform expression is a ubiquitous mechanism to enhance proteome diversity and maintain cell homeostasis. Mechanisms such as splicing that drive gene isoform variability …