Gamma delta T cells (γδ T cells) are T cells that have a γδ T-cell receptor (TCR) on their surface. Most T cells are αβ (alpha beta) T cells with TCR composed of two glycoprotein chains called α (alpha) and β (beta) TCR chains. In contrast, γδ T cells have a TCR that is made up of one γ (gamma) chain and one δ (delta) chain.

Jul 24, 2020 · To date, diverse and largely host-cell-derived molecules have been identified as cognate antigens for the γδ TCR. However, for most γδ TCRs, the activating ligand is still unknown and many open...

On the one hand, clonally expanded γδ T cells with unique specificities typify adaptive immunity. Conversely, large compartments of γδTCR + intraepithelial lymphocytes (γδ IELs) exhibit limited TCR diversity and effect rapid, innate-like tissue surveillance.

Apr 24, 2024 · Gamma delta (γδ) T cells, a unique T cell subgroup, are crucial in various immune responses and immunopathology 1, 2, 3. The γδ T cell receptor (TCR), which is generated by γδ T cells,...

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Nov 12, 2018 · Hence, the γδTCR intrinsically combines innate immunity and adaptive immunity by using spatially distinct regions to discriminate non-clonal agonist-selecting elements from clone-specific...

Here, we reveal a regulatory axis where T cell receptor (TCR) signaling controls TCF1 expression through an E-protein-bound regulatory element in the locus, and this. axis regulates both gd T lineage commitment and effector fate.

May 1, 2002 · γδ T cell receptors (γδ TCRs), αβ T cell receptors (αβ TCRs) and antibodies are all products of gene rearrangement that provide the vertebrate immune system with the ability to recognize a diverse array of antigenic molecules.

Mar 28, 2019 · In this review, we will discuss the current state of knowledge of the molecular mechanism of TCR signal transduction and its role in the thymic development of γδT cells, particularly highlighting a newly discovered mechanism that …

Oct 8, 2019 · In contrast to the previous assumption of the general allo-HLA reactivity of a minor fraction of γδTCRs, we show that classic anti-HLA–directed, γδTCR-mediated reactivity can selectively act on hematological and solid tumor cells, while not harming healthy tissues in …