Growth differentiation factor 11 (GDF11), also known as bone morphogenetic protein 11 (BMP-11), is a protein that in humans is encoded by the growth differentiation factor 11 gene. [5] …

The cause of this anti-aging phenomenon remained a mystery until May 2013, when Wagers, PhD, and cardiologist Richard Lee, MD, found that a protein in the blood of young mice, called …

Growth differentiation factor 11 (GDF11), a member of the transforming growth factor β superfamily of cytokines, is a critical rejuvenation factor in aging cells. GDF11 improves …

Nov 17, 2023 · In vitro GDF11 deletion causes cellular senescence in Neuro-2a cells. Mechanistically, GDF11 deletion induces neuronal senescence via Smad2-induced …

Dec 25, 2024 · GDF11 (Growth Differentiation Factor 11) is a Protein Coding gene. Diseases associated with GDF11 include Vertebral Hypersegmentation And Orofacial Anomalies and …

Feb 8, 2025 · GDF-11 promotes human trophoblast cell invasion by increasing ID2-mediated MMP2 expression. Growth differentiation factor 11 induces skeletal muscle atrophy via a …

Bone Morphogenetic Protein 11 (BMP 11) or Growth/Differentiation Factor 11 (GDF 11) is a BMP/Transforming Growth Factor β (TGF β) family member protein that is globally secreted in …

Growth differentiation factor (GDF11) is a member of TGF-β/BMP superfamily that activates Smad and non-Smad signaling pathways and regulates expression of its target nuclear genes.

Jun 1, 2023 · GDF11 (Growth differentiation factor 11) is a newly discovered member of family of transforming growth factors-β. Its crucial role was confirmed in physiology, i.e. embryogenesis …

Apr 1, 2016 · GDF11 is essential for mammalian development and has been suggested to regulate aging of multiple tissues, whereas myostatin is a well-described negative regulator of …

Jun 1, 2023 · Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor-β superfamily that has garnered significant attention due to its anti-cardiac aging …

GDF11 is expressed in many tissues, including skeletal muscle, pancreas, kidney, nervous system, and retina, among others. GDF11 circulating levels and protein content in tissues are …

GDF11 is a secreted factor in the TGFß family of cytokines. Its nearest neighbor evolutionarily is myostatin, a factor discovered as being a negative regulator of skeletal muscle growth.

Feb 2, 2023 · Here, we demonstrate that systemic administration of growth differentiation factor 11 (GDF11) in aged mice improves memory and alleviates senescence and depression-like …

Growth differentiation factor 11 (GDF11), also known as bone morphogenetic protein 11 (BMP11), has been identified as a key player in various biological processes, including embryonic …

Jun 1, 2023 · Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor-β superfamily that has garnered significant attention due to its anti-cardiac aging …

Dec 8, 2020 · Growth differentiation factor 11 (GDF11), a member of the transforming growth factor β superfamily of cytokines, is a critical rejuvenation factor in aging cells. GDF11 …

The cardiovascular role of growth differentiation factor (GDF)-11, a member of the transforming growth factor (TGF)-β superfamily, is controversial. In 2013, we reported that heterochronic …