2024年12月25日 · GBP1 (Guanylate Binding Protein 1) is a Protein Coding gene. Diseases associated with GBP1 include Ulceroglandular Tularemia and Kaposi Sarcoma. Among its related pathways are Antiviral mechanism by IFN-stimulated genes and Cytokine Signaling in …

内源性 gbp1 是细胞死亡或细菌杀灭所需的唯一 gbp. 人类 gbp1、gbp2、gbp3 和 gbp4 已被建议在细菌膜上形成复合物，这对细胞焦亡和细菌杀灭至关重要。 然而，在上皮细胞中，仅测试了 gbp1 的敲除细胞，而使用 sirna 靶向其他 gbp 以降低表达。

Interferon-induced guanylate-binding protein 1 is a protein that in humans is encoded by the GBP1 gene. [3][4] It belongs to the dynamin superfamily of large GTPases. [5] Guanylate binding protein expression is induced by interferon.

2020年1月23日 · Guanylate-binding protein 1 (GBP1) is a large GTPase of the dynamin superfamily involved in the regulation of membrane, cytoskeleton, and cell cycle progression dynamics.

2024年3月4日 · 研究人员利用冷冻电镜断层成像（cryo-electron tomography， cryo-ET）技术首次捕捉GBP1与病原微生物表面的相互作用。 GBP1采用 一种全新的“直立”的锚定构象并且以多聚的方式快速富集在细菌表面。 这一富集导致了细菌 外膜的 破坏，释放了革兰氏阴性细胞外膜的脂多糖（LPS），来激活并诱导细胞焦亡。 作者首先使用共聚焦荧光显微镜，作者发现了GBP1-4的整体复合物在细菌表面形成是严格依赖于GBP1与细菌表面的先行接触。 GBP1 和Caspase-4 一 …

2022年2月22日 · GBP1 identifies gram-negative bacteria such as the enteric pathogen, Salmonella enterica serovar Typhimurium, that enter the cytoplasm of the host cell. GBP1 then quickly connects to LPS and stimulates the assembly of more …

2020年1月24日 · Guanylate-binding protein 1 (GBP1) is a large GTPase of the dynamin superfamily involved in the regulation of membrane, cytoskeleton, and cell cycle progression dynamics. In many cell types, such as endothelial cells and monocytes, GBP1 expression is strongly provoked by interferon γ (IFNγ) and acts …

2022年2月18日 · GBP1 identifies gram-negative bacteria such as the enteric pathogen, Salmonella enterica serovar Typhimurium, that enter the cytoplasm of the host cell. GBP1 then quickly connects to LPS and stimulates the assembly of more GBPs in the order of GBP2, GBP3, and GBP4. Subsequently, inflammatory caspase-4 arrives at the GBP1–4 activation platform.

2019年7月1日 · Here we report that Toxoplasma-induced death of human macrophages requires GBP1 and its ability to target Toxoplasma parasitophorous vacuoles through its GTPase activity and prenylation. Mechanistically, GBP1 promoted Toxoplasma detection by AIM2, which induced GSDMD-independent, ASC-, and caspase-8-dependent apoptosis.

2017年10月12日 · 鸟苷酸结合蛋白GBP（Interferon-inducible guanylate-binding proteins）在天然免疫通路中被干扰素诱导表达，是近年来该科研领域的明星分子。 GBP蛋白是一类非常保守且庞大的家族，在人的基因组中有7个同源基因，而在小鼠的基因组中多达11个【1,2】。 之前该领域的研究发现多种胞内侵染型的细菌感染细胞时，GBP蛋白会像LC3蛋白一样，包裹到细菌周围。