GATA3 is a transcription factor that in humans is encoded by the GATA3 gene. Studies in animal models and humans indicate that it controls the expression of a wide range of biologically and clinically important genes.

2024年12月2日 · Poorly differentiated breast carcinoma. A biopsied liver lesion is radiographically suspected to be a metastasis of unknown primary. Which stain combination would be most consistent with metastasis from a breast primary? C. GATA3 positive, ER …

2024年12月25日 · GATA3 (GATA Binding Protein 3) is a Protein Coding gene. Diseases associated with GATA3 include Hypoparathyroidism, Sensorineural Deafness, And Renal Dysplasia Syndrome and Hypoparathyroidism-Deafness-Renal Disease Syndrome. Among its related pathways are Gene expression (Transcription) and ESR-mediated signaling.

GATA-3 is particularly important in the development of T cells and is a key regulator in the immune system, influencing the development of the Th2 (T helper 2) cell lineage, which is …

2014年11月20日 · GATA binding protein 3 (GATA3) is a regulator of mammary luminal cell differentiation, and an estrogen receptor (ER) associated marker in breast cancer. Tumor suppressor functions of GATA3 have been demonstrated primarily in basal-like breast cancers.

2024年6月18日 · "GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.". Am J Surg Pathol 38 (1): 13-22. doi : 10.1097/PAS.0b013e3182a0218f .

2024年12月22日 · GATA3 also modulates cell differentiation, proliferation, and apoptosis via controlling gene expression. In physiological instances, GATA3 is crucial for maintaining immunological homeostasis by mediating the development of naïve T cells into T helper 2 (Th2).

GATA3 regulates gene expression through binding nucleosomal DNA and facilitating chromatin remodelling. Post-translational modifications modulate its activity. During development, GATA3 plays a key role in cell differentiation. Mutations in GATA3 are linked to …

GATA-3 is the main GATA family member that is expressed in immune cells and can be easily detected in developing and mature T cells, natural killer (NK) cells, and CD1-restricted natural killer T (NKT) cells.

2022年6月29日 · Mouse monoclonal anti-GATA3 demonstrates a strong diffuse and nuclear reaction in neoplastic cells of invasive ductal carcinoma of the breast.