Gamma-glutamyl carboxylase oxidizes vitamin K hydroquinone to Vitamin K-2,3-epoxide, while simultaneously adding CO 2 to protein-bound glutamic acid (abbreviation = Glu) to form …

2025年1月29日 · Structural and cellular assays and molecular dynamics simulations reveal the mechanism of action of γ-glutamyl carboxylase, which involves cholesterol and vitamin K.

γ-Glutamyl carboxylase is an integral membrane glycoprotein that requires vitamin K to activate posttranslational modification of glutamate (Glu) to γ-carboxyl glutamate (Gla) in specific …

Vitamin K-dependent (VKD) carboxylation is a post-translational modification that converts specific glutamate residues (Glu) to gamma-carboxyglutamate residues (Gla) in VKD proteins.

2024年3月1日 · Vitamin K is a cofactor for the enzymatic conversion of select glutamic acid (Glu) residues in vitamin K-dependent proteins into gamma-carboxyglutamic acid (Gla), which has …

2025年3月4日 · The enzyme gamma-glutamyl carboxylase (GGCX) facilitates the activation of vitamin K-dependent proteins through carboxylation. The study revealed that cholesterol …

The gamma-glutamyl carboxylase produces Gla using reduced vitamin K, which becomes oxygenated to vitamin K epoxide. Reduced vitamin K is then regenerated by a vitamin K …

2025年3月4日 · These proteins are not only pivotal for clotting but also for bone and heart health, energy metabolism, brain development, and fertility, among other roles. Vitamin K activates …

Die Gamma-Glutamylcarboxylase, kurz GGCX, ist ein Enzym, das an der Blutgerinnung beteiligt ist und am stärksten in der Leber exprimiert wird. Funktion Die Gamma-Glutamylcarboxylase …

Carboxylation is catalyzed by the enzyme gamma-glutamyl carboxylase (GGCX), which utilizes a reduced form of vitamin K (KH 2), carbon dioxide and oxygen as cofactors. Concomitant with …