2024年12月25日 · GAB2 (GRB2 Associated Binding Protein 2) is a Protein Coding gene. Diseases associated with GAB2 include Noonan Syndrome-Like Disorder With Loose Anagen …

Gab2, a key member of the Gab family of proteins, is involved in the amplification and integration of signal transduction, evoked by a variety of extracellular stimuli, including growth factors, …

2021年4月8日 · Gab2 (Grb2-associated binder2) silencing or deficiency inhibits TNFα (tumor necrosis factor alpha)-induced, IL (interleukin)-1β–induced, or lipopolysaccharide (LPS) …

GAB2 is the limiting component of the GAB2-SHP2 complex, signaling Erk MAP kinase activation and terminal differentiation of K562 CML cells. The docking protein Gab2 is overexpressed …

GAB2 is essential for two major signal transduction pathways in cancer, the PI3-K-AKT and extracellular signal-regulated kinase (ERK) signaling pathways, and thus regulates a number …

2025年2月8日 · Gab2 promotes the growth of colorectal cancer by regulating the M2 polarization of tumor-associated macrophages. The Gab2-MALT1 axis regulates thromboinflammation and …

2015年3月1日 · Gab2 (Grb2-associated binder 2), a member of the DOS/Gab family of scaffolding adapters, serves as a critical signal amplifier downstream of various growth factor receptors. …

2015年3月1日 · Recent studies have identified that Gab2 is overexpressed in several cancer types and that increased Gab2 expression promotes cell proliferation, cell transformation, and …

Recent studies have highlighted that the Grb2-associated binder 2 (Gab2) is a critical gene involved in the development of various types of tumor, including CRC. However, the precise …

Gab2 functions to mediate the activation of critical cell signaling pathways by multiple cell surface receptors for growth factors, cytokines, antigens, and immunoglobulins (Fig. 2).