Dec 25, 2024 · GAB1 (GRB2 Associated Binding Protein 1) is a Protein Coding gene. Diseases associated with GAB1 include Deafness, Autosomal Recessive 26 and Glioblastoma. Among …

GRB2-associated-binding protein 1 is a protein that in humans is encoded by the GAB1 gene. [5] The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein …

Gab1 is a multiadaptor protein that has been shown to be required for multiple processes in embryonic development and oncogenic transformation. Gab1 functions by amplifying signal …

We demonstrate that Gab1 is essential for FGF1 stimulation of both PI 3-kinase and the antiapoptotic protein kinase Akt, while FGF1-induced mitogen-activated protein kinase (MAPK) …

Mar 11, 2003 · Grb2-associated binder-1 (Gab1) is a pleckstrin homology (PH) domain-containing adapter molecule that is believed to function downstream of receptors for growth factors and …

Feb 8, 2025 · Gab1 is a unique negative regulator of the thymus-independent antigen-2 response specifically expressed in splenic marginal zone B cells. coupling of Gab1 to PI3K is important …

Aug 20, 2023 · GRB2-associated binder 1 (GAB1) is the inaugural member of the GAB/DOS family of pleckstrin homology (PH) domain-containing proteins. Upon receiving various stimuli, …

Oct 24, 2019 · Grb2-associated binder (Gab) family proteins are multi-site docking proteins, which expand cytokine-induced signal transduction in a spatial- and time-dependent manner by …

Oct 9, 2016 · Title: Activated Gab1 drives hepatocyte proliferation and anti-apoptosis in liver fibrosis via potential involvement of the HGF/c-Met signaling axis. Association of GAB1 gene …

Gab1 is phosphorylated by c-Met and by other receptor and nonreceptor tyrosine kinases. Here, we report the functional analysis of Gab1 by targeted mutagenesis in the mouse, and compare …