2024年12月25日 · GSTP1 (Glutathione S-Transferase Pi 1) is a Protein Coding gene. Diseases associated with GSTP1 include Kala-Azar 2 and Hepatocellular Adenoma. Among its related pathways are Metapathway biotransformation Phase I and II and Innate Immune System.

This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]

Glutathione S-transferase Pi 1 (GSTP1) is an enzyme with an important antioxidant role and is encoded for by the GSTP1 gene. Glutathione is an important antioxidant molecule which readily neutralizes reactive oxygen species, a major cause of oxidative stress, on other molecules 1 .

The GSTP1 gene, encoding the pi class glutathione S-transferase, was the first hypermethylated gene to be characterized in prostate cancer. GSTP1 is thought to protect prostate epithelial cells from carcinogen-associated and\or oxidative stress-induced DNA damage, and loss of GSTP1 may render prostate cells unprotected from such genomic insults.

Glutathione transferase P1-1 (GSTP1-1) is expressed in some human tissues and is abundant in mammalian erythrocytes (here termed e-GST). This enzyme is able to detoxify the cell from endogenous and exogenous toxic compounds by using …

2019年1月25日 · In the current study, we found a novel mechanism by which GSTP1 protects human breast cancer cells from adriamycin (ADR)-induced cell death and contributes to the drug resistance. GSTP1 protein...

The glutathione S-transferase P1 (GSTP1) is involved in multiple cellular functions, including phase II metabolism, stress response, signaling, and apoptosis. The mechanisms underlying the significantly high GSTP1 expression in many human tumors ...

2018年1月24日 · Monomeric GSTP1 protects tumoral cells from apoptosis by inhibition of the JNK signaling pathway through the formation of a GSTP1-JNK-cJun complex that hampers c-Jun phosphorilation.

2020年12月23日 · A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of glutathione S-transferase pi 1 (GSTP1) expression by HIV-1 Vpr in Vpr transduced macrophages

The silencing of GSTP1 via promoter hypermethylation is a well-documented epigenetic alteration in several cancers, such as prostate, breast, and lung cancer (Cui et al., 2006). In HCC, the GSTP1 promoter is frequently hypermethylated, leading to gene silencing and a loss of the protective detoxification function.