2024年12月25日 · GSK3B (Glycogen Synthase Kinase 3 Beta) is a Protein Coding gene. Diseases associated with GSK3B include Cardiomyopathy, Familial Hypertrophic, 1 and Hematologic Cancer. Among its related pathways are Signaling by GSK3beta mutants and IL-9 Signaling Pathways.

2021年11月27日 · Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with over 100 known substrates to deal with. How does GSK3 maintain control to selectively phosphorylate each substrate, and why was it evolutionarily favorable for GSK3 to assume such a large responsibility?

GSK3B controls GFI1 expression via phosphorylation of Serine 94 and Serine 98 sites, which leads to SCFFBXW7-mediated polyubiquitination and proteasome degradation. Low GSK3B expression is associated with cell proliferation, migration, and invasion in renal carcinoma.

GSK-3β is essential for the control of glucose metabolism, signal transduction, and tissue homeostasis. As more than 100 known proteins have been identified as GSK-3β substrates, it is sometimes referred to as a moonlighting kinase. Previous studies have elucidated the regulation modes of GSK-3β.

2022年12月15日 · Glycogen synthase kinase 3 beta — or just “GSK3β” for short — is an enzyme that has been linked to many important functions throughout the body and brain, including energy metabolism, neuronal cell development, and the regulation of the immune system [1].

Glycogen synthase kinase (GSK)3β is an isoform of the GSK3 family of kinases. It regulates many fundamental biological processes in cells by phosphorylating serine and threonine residues and thus interacting with more than 100 functional and structural proteins [1, 2, 3, 4].

Glycogen Synthase Kinase 3 (GSK3) is one of the Serine/Threonine protein kinases, which has gained a lot of attention for its role in a variety of pathways. It has two isoforms, GSK3α and GSK3β. However, GSK3β is highly expressed in different areas of the brain and has been implicated in Alzheimer's disease as it is involved in tau phosphorylation.

Glycogen synthase kinase-3β (GSK-3β) is an evolutionarily conserved serine/threonine kinase, functioning in numerous cellular processes including cell proliferation, DNA repair, cell cycle, signaling and metabolic pathways. GSK-3β is implicated in different diseases including inflammation, neurodegenerative disease, diabetes and cancers.

Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (PubMed: 18846110).

2016年11月22日 · Clinical resource with information about GSK3B, Discovery and refinement of loci associated with lipid levels., and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.