Glucose-regulated protein 94 is the HSP90-like protein in the lumen of the endoplasmic reticulum and therefore it chaperones secreted and membrane proteins. It has essential functions in …

2024年5月29日 · Here, we show that GRP94 was involved in β cell adaption and compensation (or failure) in islets from leptin receptor-deficient (db/db) mice in an age-dependent manner. …

GRP94 is a ubiquitously expressed chaperone, with especially high levels in secretory tissues (http://biogps.gnf.org). Though its up-regulation is often used as a hallmark of responses to ER …

In this chapter, we discuss the biology and structure-function relationship of GRP94. We also summarize the immunological roles of GRP94 based on the studies documented over the last …

2021年3月17日 · Glucose-regulated protein 94 (GRP94) is an endoplasmic reticulum (ER)-resident member of the heat shock protein 90 (HSP90) family. In physiological conditions, it …

2021年1月22日 · In this work, we studied GRP94 in M1/LPS + IFNγ and M2/IL-4 primary macrophages derived from human monocytes (isolated from buffy coats), in basal and ER …

2021年3月17日 · Glucose-regulated protein 94 (GRP94) is an endoplasmic reticulum (ER)-resident member of the heat shock protein 90 (HSP90) family. In physiological conditions, it …

2018年1月1日 · Grp94 is the endoplasmic reticulum (ER) paralog of heat shock protein (Hsp) 90. This chaperone/stress protein belongs to the protein family of glucose-regulated proteins …

GRP94 is a glucose-regulated protein of 94 kDa molecular size, encoded by the gene HSP90B1 (OMIM #191175), whose chromosomal location is remarkably close to the IGF-I gene.

2012年3月1日 · GRP94 is an endoplasmic reticulum resident chaperone that belongs to HSP90 family. GRP94 chaperones secreted and membrane proteins. GRP94 is essential in …