The GPIb-IX-V complex is a profuse membrane receptor complex originating in megakaryocytes and exclusively functional on the surface of platelets. [1] It primarily functions to mediate the …

Platelets bind to exposed vascular matrix at a wound site through a highly specialized surface receptor, glycoprotein (GP) Ib-IX-V complex, which recognizes von Willebrand factor (VWF) in …

2022年4月2日 · GPV, which contains 15 leucine-rich repeats, a transmembrane domain, and a short cytoplasmic tail is weakly associated with the GPIb-IX complex by transmembrane …

Glycoprotein (GP) Ib-IX-V is a remarkable platelet adhesion receptor of the leucine-rich repeat family. It has evolved to fulfil its major function of initiating platelet aggregation (thrombus …

2019年1月1日 · GPIb-IX-V signaling leads to platelet activation and aggregation (e.g., binding to immobilized VWF at the site of injury), and platelet clearance (e.g., binding to soluble VWF or …

This review summarizes forces driving the assembly of the GPIb-IX-V complex, discusses their implication on the pathogenesis of Bernard-Soulier syndrome, and identifies questions that …

The GPIb-V-IX complex has a binding site for thrombin on GPIb alpha which participates in the platelet activation by that agonist. GPV is also cleaved by thrombin but the function of this …