14672 Ensembl ENSG00000088256 ENSMUSG00000034781 UniProt P29992 P21278 RefSeq (mRNA) NM_002067 NM_010301 RefSeq (protein) NP_002058 NP_034431 Location (UCSC) Chr 19: 3.09 – 3.12 Mb Chr 10: 81.36 – 81.38 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Guanine nucleotide-binding protein subunit alpha-11 is a protein that in …

GNAQ and GNA11 genes encode protein members of the q class of G-protein alpha subunits involved in mediating signals between G-protein coupled receptors (GPCRs) and downstream effectors . Both genes have mainly been considered as driver genes in carcinogenesis, as they lead to constitutive activation of GPCR signalling.

2024年12月25日 · GNA11 (G Protein Subunit Alpha 11) is a Protein Coding gene. Diseases associated with GNA11 include Hypocalciuric Hypercalcemia, Familial, Type Ii and Hypocalcemia, Autosomal Dominant 2. Among its related pathways are Thromboxane signalling through TP receptor and Development Angiotensin activation of ERK.

The GNA11 gene provides instructions for making one component, the alpha (α) subunit, of a protein complex called a guanine nucleotide-binding protein (G protein). Learn about this gene and related health conditions.

Our findings indicate that the germline gain-of-function mutation of GNA11 is a cause of autosomal dominant hypoparathyroidism and implicate a novel role for GNA11 in skeletal growth. Metastatic uveal melanoma with GNAQ or GNA11 mutations is responsive to PKC inhibitors.

2010年12月2日 · We found somatic mutations in exon 5 (affecting Q209) and in exon 4 (affecting R183) in both GNA11 and GNAQ, in a mutually exclusive pattern. Mutations affecting Q209 in GNA11 were present in...

2024年6月17日 · Title: In uveal melanoma Gα-protein GNA11 mutations convey a shorter disease-specific survival and are more strongly associated with loss of BAP1 and chromosomal alterations than Gα-protein GNAQ mutations.

GNA11 (guanine nucleotide binding protein (G protein), alpha 11 (Gq class)) is a gene that encodes the guanine nucleotide-binding protein subunit alpha-11, a subunit of one of the heterotrimeric guanine nucleotide binding proteins (G proteins).

2021年9月22日 · Mice injected with cells transduced with the GNA11 Q209L mutation developed rapidly growing tumors and metastases, whereas injection with GNA11 R183C-transduced cells showed lesser potency. Western blot analysis of melanocytes transduced with Q209L showed constitutive activation of the MAPK pathway.

2025年2月8日 · Enables G protein activity and enzyme regulator activity. Involved in several processes, including G protein-coupled receptor signaling pathway; ligand-gated ion channel signaling pathway; and positive regulation of insulin secretion.