Glucose transporter 3 (or GLUT3), also known as solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) is a protein that in humans is encoded by the SLC2A3 gene. [1] GLUT3 facilitates the transport of glucose across the plasma membranes of mammalian cells.

The GLUT3 −/+ fetuses demonstrated an intermediate expression of GLUT3 at both blastocyst stage and postimplantation and survived but were growth retarded with a 20% peak decline in body weight compared with controls.

GLUT3 protein is located mainly in the brain where it is responsible for glucose uptake into neurons, and GLUT4 is the major glucose transporter in adipocytes and skeletal and cardiac muscle. GLUT5 is not a glucose transporter; instead it is a fructose transporter expressed in the brush border membrane of enterocytes.

Facilitative sugar transporters (GLUTs) are the primary method of sugar uptake in all mammalian cells. There are 14 different types of those transmembrane proteins, but they transport only a handful of substrates, mainly glucose and fructose.

Neurons obtain glucose from extracellular environment for energy production mainly depending on glucose transporter 3 (GLUT3). GLUT3 uptakes glucose with high affinity and great transport capacity, and is important for neuronal energy metabolism.

2015年7月15日 · GLUT3 is known as the 'neuronal glucose transporter' for its primary function in neurons, but it is also required for glucose uptake in sperm, pre-implantation embryos, and circulating white...

GLUT3 is important for mouse embryo development and (together with GLUT1) with the supply of glucose to the foetus [77, 192]. GLUT3 is upregulated in response to hypoxia , and this upregulation is mediated by the transcription factor HIF, …

What is it about GLUT3 that specifically suits the needs of the highly metabolic and oxidative neuron with its high glucose demand? More recently, GLUT3 has been studied in other cell types with quite specific requirements for glucose, including sperm, preimplantation embryos, circulating white blood cells, and an array of carcinoma cell lines.

Decreased α-granule degranulation is due in part to an impaired ability of GLUT3 to potentiate exocytosis. Conclusions: GLUT3-mediated glucose utilization and glycogenolysis in platelets promotes α-granule release, platelet activation, and postactivation functions.

Glucose Transporter 3 (GLUT3) is a specific glucose transporter protein predominantly expressed in neurons, facilitating the uptake of glucose into the cell bodies rather than the axon terminal compartment.