Glial fibrillary acidic protein (GFAP) is an intermediate filament structural protein involved in cytoskeleton assembly and integrity, expressed in high abundance in activated glial cells. GFAP is neuroprotective, as knockout mice are hypersensitive to traumatic brain injury.

2022年2月3日 · Glial fibrillary acidic protein (GFAP) levels reflect the clinical severity and extent of intracranial pathology after traumatic brain injury (TBI).

GFAP stands for glial fibrillary acidic protein. It is a protein found in certain cells of the nervous system and in the salivary glands. GFAP helps maintain the structure and function of these cells, particularly in the brain and spinal cord.

The GFAP gene provides instructions for making a protein called glial fibrillary acidic protein. This protein is a member of the intermediate filament family of proteins. Intermediate filaments form networks that provide support and strength to cells.

Antibodies (Ab) targeting GFAP have been identified as the biomarker of a recently reported disorder: autoimmune GFAP astrocytopathy. 1 Detection of GFAP-Ab is recommended in the CSF by indirect immunofluorescence on rat brain tissues and cell-based assays (IFA and CBA) using GFAPα. 2 Autoimmune GFAP astrocytopathy is a rare entity that has ...

2024年12月25日 · GFAP (Glial Fibrillary Acidic Protein) is a Protein Coding gene. Diseases associated with GFAP include Alexander Disease and Canavan Disease . Among its related pathways are Signaling by ERBB4 and Selective autophagy .

Glial Fibrillary Acidic Protein (GFAP) is a major protein found in the astrocytic cells of the brain, and it is considered a marker of astrogliosis, which is a characteristic feature of multiple sclerosis (MS) lesions.

Glial fibrillary acidic protein (GFAP) is an intermediate filament (IF) III protein uniquely found in astrocytes in the central nervous system (CNS), non-myelinating Schwann cells in the peripheral nervous system (PNS), and enteric glial cells.

GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.

Glial fibrillary acidic protein (GFAP) is the hallmark intermediate filament (IF; also known as nanofilament) protein in astrocytes, a main type of glial cells in the central nervous system (CNS). Astrocytes have a range of control and homeostatic functions in health and disease.