Glial cell line-derived neurotrophic factor (GDNF) is a protein that, in humans, is encoded by the GDNF gene. [5] GDNF is a small protein that potently promotes the survival of many types of neurons. [6] It signals through GFRα receptors, particularly GFRα1.

Glial cell line-derived neurotrophic factor (GDNF) was originally purified from a rat glioma cell-line supernatant as a trophic factor for embryonic midbrain dopamine neurons, and was...

2024年12月25日 · GDNF (Glial Cell Derived Neurotrophic Factor) is a Protein Coding gene. Diseases associated with GDNF include Hirschsprung Disease 3 and Congenital Central Hypoventilation Syndrome. Among its related pathways are MAPK family signaling cascades and Kidney development.

The GDNF family of ligands (GFL) consists of four neurotrophic factors: glial cell line-derived neurotrophic factor (GDNF), neurturin (NRTN), artemin (ARTN), and persephin (PSPN). GFLs have been shown to play a role in a number of biological processes including cell survival, neurite outgrowth, cell differentiation and cell migration.

2024年7月1日 · GDNF (glial cell line derived neurotrophic factor) GDNF was first discovered in 1993 and is the most studied growth factor in Parkinson’s. Early lab studies showed that GDNF has powerful effects on dopamine-producing cells grown in a dish.

In a healthy adult brain, glial cell line-derived neurotrophic factor (GDNF) is exclusively expressed by neurons, and, in some instances, it has also been shown to derive from a single neuronal subpopulation. Secreted GDNF acts in a paracrine ...

2021年10月24日 · Glial cell line-derived neurotrophic factor (GDNF) is an essential growth factor for the kidneys, spinal cord, exerting a wide range of effects on addiction, Alzheimer's, Parkinson's, neuropathy, gut inflammation, and more.

The glial cell line–derived neurotrophic factor (GDNF) family of ligands (GFLs) comprising of GDNF, neurturin, artemin, and persephin plays an important role in the development and maintenance of the central and peripheral nervous system, renal morphogenesis, and spermatogenesis.

1993年5月21日 · A potent neurotrophic factor that enhances survival of midbrain dopaminergic neurons was purified and cloned. Glial cell line-derived neurotrophic factor (GDNF) is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-β superfamily.

2024年9月15日 · Glial cell line-derived neurotrophic factor (GDNF) is a protein that’s critical for optimal brain function and mental health. It plays an important role in the survival and growth of certain types of neurons in the brain and nervous system.