Dec 25, 2024 · GDAP1 (Ganglioside Induced Differentiation Associated Protein 1) is a Protein Coding gene. Diseases associated with GDAP1 include Charcot-Marie-Tooth Disease, Type 4A and Charcot-Marie-Tooth Disease, Axonal, Type 2K. Among its related pathways are Peroxisomal lipid metabolism and Intracellular trafficking proteins involved in CMT neuropathy.

Ganglioside-induced differentiation-associated protein 1 is a type of protein that in humans is encoded by the GDAP1 gene. [5] [6] This gene encodes a member of the ganglioside-induced differentiation-associated protein family, which may play a role in a signal transduction pathway during neuronal development.

Jun 3, 2022 · Charcot-Marie-Tooth (CMT) disease 4A is an autosomal-recessive polyneuropathy caused by mutations of ganglioside-induced differentiation-associated protein 1 (GDAP1), a putative...

May 11, 2004 · GDAP1-related hereditary motor and sensory neuropathy (GDAP1-HMSN) is a peripheral neuropathy (also known as a subtype of Charcot-Marie-Tooth disease) that typically affects the lower extremities earlier and more severely than the upper extremities.

Feb 9, 2025 · GDAP1 is broadly expressed in cancer cell lines of different tissue origin. There is a consensus YY1 binding site in the GDAP1 core promoter. GDAP1 mutations should be considered both in recessive and sporadic cases of early …

Nov 14, 2016 · GDAP1 expression induces fission of mitochondria and peroxisomes by a currently elusive mechanism, while disease causing mutations in GDAP1 impede the protein’s role in mitochondrial dynamics. In...

The GDAP1 gene encodes a protein expressed in the central and peripheral nervous system, particularly in Schwann cells. GDAP1 is an integral membrane protein of the outer mitochondrial membrane (Niemann et al., 2005).

Ganglioside-induced differentiation-associated protein (GDAP1) encodes a ganglioside-induced differentiation-associated protein originally isolated using a tetracycline-regulated expression system from differentiated Neuro2a cells (148).

gdap1是线粒体裂变因子之一，隐性遗传方式通过功能丧失机制降低线粒体裂变活性，导致线粒体的碎裂和管状线粒体的扩大；而显性遗传则干扰线粒体融合、增加活性氧簇的产生，造成线粒体跨膜电位不均匀，导致线粒体损伤，增强细胞对凋亡刺激的敏感性，这 ...

Feb 8, 2025 · GDAP1 mutations differ in their effects on mitochondrial dynamics and apoptosis depending on the mode of inheritance. Niemann A, Wagner KM, Ruegg M, Suter UNiemann A, et al. Neurobiol Dis, 2009 Dec. PMID 19782751