GATA3 is a transcription factor that in humans is encoded by the GATA3 gene. Studies in animal models and humans indicate that it controls the expression of a wide range of biologically and clinically important genes.

2024年12月2日 · Poorly differentiated breast carcinoma. A biopsied liver lesion is radiographically suspected to be a metastasis of unknown primary. Which stain combination would be most consistent with metastasis from a breast primary? C. GATA3 positive, ER …

A recent study found GATA-3 to be associated with favorable breast cancer pathologic features, including negative lymph node and positive estrogen receptor (ER) status. GATA-3 levels were also found to be an independent prognostic marker, with low expression predicting for breast cancer recurrence.

GATA3 binding protein, commonly and from here on abbreviated as GATA3, is a transcription factor of the GATA family. These nuclear proteins recognize G-A-T-A nucleotide sequences in target gene promoters and activate or repress those genes.

2024年12月25日 · GATA3 (GATA Binding Protein 3) is a Protein Coding gene. Diseases associated with GATA3 include Hypoparathyroidism, Sensorineural Deafness, And Renal Dysplasia Syndrome and Hypoparathyroidism-Deafness-Renal Disease Syndrome. Among its related pathways are Gene expression (Transcription) and ESR-mediated signaling.

In immune cells, GATA3 is best known to function as a master regulator of T helper 2 (T H 2)-cell differentiation. However, in recent years GATA3 has been found to have additional...

GATA-3 is particularly important in the development of T cells and is a key regulator in the immune system, influencing the development of the Th2 (T helper 2) cell lineage, which is involved in the immune response to parasites and allergic reactions.