Glutamic acid decarboxylase 67 (GAD67) is one of the isoforms that catalyze GABA synthesis. Subcutaneous inoculation of the GAD-expressing HSV vector transduces DRG neurons to …

Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the central nervous system, synthesized by two isoforms of glutamate decarboxylase (GAD): GAD65 and GAD67. …

We reveal a novel and specific role of GAD67-mediated GABA synthesis and signaling in regulating the maturation of inhibitory innervation pattern in the adolescent mouse visual cortex.

Dec 17, 2014 · Glutamate decarboxylase exists as two major isoforms, termed GAD65 and GAD67, that are usually expressed in GABA-containing neurons in the central nervous …

May 26, 2020 · Antibodies to glutamic acid decarboxylase (GAD) have been associated with several neurological syndromes, including stiff-person syndrome, cerebellar ataxia and …

Apr 23, 2015 · Decreased expression of the GABA synthetic enzyme glutamate decarboxylase 67 (GAD67) in a subset of GABAergic neurons, including parvalbumin (PV)-expressing neurons, …

Dec 1, 2002 · The exon-intron organization of the genes (GAD1 and GAD2) encoding two human glutamate decarboxylases (GAD67 and GAD65) suggests that they derive from a common …

Mar 25, 2007 · Gamma-aminobutyric acid (GABA) is synthesized by two isoforms of the pyridoxal 5′-phosphate–dependent enzyme glutamic acid decarboxylase (GAD65 and GAD67). GAD67 …

Although GAD65 and GAD67 differ significantly in several characteristics, they also have substantial similarities and interactions, and the presence of individual forms of GAD in certain …

GAD67, the larger isoform of theg-aminobutyric acid- synthesizing enzyme glutamic acid decarboxylase, is a hydrophilic soluble molecule, postulated to localize at nerve terminals and …